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TPD52 tumor protein D52 [ Homo sapiens (human) ]

Gene ID: 7163, updated on 7-Apr-2024

Summary

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Official Symbol
TPD52provided by HGNC
Official Full Name
tumor protein D52provided by HGNC
Primary source
HGNC:HGNC:12005
See related
Ensembl:ENSG00000076554 MIM:604068; AllianceGenome:HGNC:12005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D52; N8L; PC-1; PrLZ; hD52
Summary
Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon (RPKM 43.8), prostate (RPKM 36.3) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
8q21.13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80031082..80171564, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80462421..80603125, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80943317..81083799, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927040 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene U7 small nuclear RNA Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19315 Neighboring gene uncharacterized LOC124901966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19316 Neighboring gene TPD52-MRPS28 readthrough Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene VISTA enhancer hs1305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80894241-80894806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:80909347-80909896 Neighboring gene Sharpr-MPRA regulatory region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19317 Neighboring gene Sharpr-MPRA regulatory region 3052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27553 Neighboring gene uncharacterized LOC105375919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19318 Neighboring gene uncharacterized LOC105375918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81013977-81014477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19319 Neighboring gene uncharacterized LOC105375920 Neighboring gene RNA, 7SL, cytoplasmic 41, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19321 Neighboring gene microRNA 5708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52. Shi Q, et al. Am J Reprod Immunol, 2022 Sep. PMID 35716110
  2. Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK. Chen Y, et al. Cancer Med, 2023 Jan. PMID 35666017, Free PMC Article
  3. Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers. Shabbir M, et al. Sci Rep, 2021 Jun 7. PMID 34099820, Free PMC Article
  4. Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer. Fan Y, et al. Autophagy, 2021 Dec. PMID 34034634, Free PMC Article
  5. miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer. Ge J, et al. J Invest Surg, 2021 Sep. PMID 32166986

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
    Title: Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
  2. Cross talk of tumor protein D52 (TPD52) with KLF9, PKCepsilon, and MicroRNA 223 in ovarian cancer.
    Title: Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer.
  3. Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression.
    Title: Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression.
  4. Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.
    Title: Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.
  5. Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52.
    Title: Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52.
  6. ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression.
    Title: ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression.
  7. Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
    Title: Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
  8. Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers.
    Title: Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers.
  9. Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis.
    Title: Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis.
  10. miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer.
    Title: miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough TPD52-MRPS28

Readthrough gene: TPD52-MRPS28, Included gene: MRPS28

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in secretion TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor protein D52
Names
prostate and colon associated protein
prostate leucine zipper
protein N8
NP_001020423.1
NP_001020424.1
NP_001274069.1
NP_001274071.1
NP_001274072.1
NP_001274073.1
NP_001374708.1
NP_001374709.1
NP_005070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025252.3 → NP_001020423.1  tumor protein D52 isoform 1

    See identical proteins and their annotated locations for NP_001020423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (1, also known as PrLZ-224) that is shorter than isoform 4.
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DC383362, GQ499327, U18914
    Consensus CDS
    CCDS34912.1
    UniProtKB/Swiss-Prot
    B7Z414, C9J502, D0UFD1, D0UFD2, D0UFD3, D0UFD4, D0UFD5, E5RKB4, P55327, Q13056, Q53EK8, Q6FGP3, Q6FGS3, Q86YZ2, Q9UCX8
    Related
    ENSP00000368391.3, ENST00000379097.7
    Conserved Domains (1) summary
    pfam04201
    Location:52 → 210
    TPD52; Tumour protein D52 family

  2. NM_001025253.3 → NP_001020424.1  tumor protein D52 isoform 2

    See identical proteins and their annotated locations for NP_001020424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, compared to variant 4. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    AC009686, AK295468, BU071387, CB128067, DA079836, DC331087, U18914
    Consensus CDS
    CCDS47879.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000429915.1, ENST00000518937.6
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 193
    TPD52; Tumour protein D52 family

  3. NM_001287140.2 → NP_001274069.1  tumor protein D52 isoform 4

    See identical proteins and their annotated locations for NP_001274069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4, also known as PrLZ-247).
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DC383362, GQ499324, U18914
    Consensus CDS
    CCDS75759.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000429309.1, ENST00000520527.5
    Conserved Domains (1) summary
    pfam04201
    Location:52 → 233
    TPD52; Tumour protein D52 family

  4. NM_001287142.2 → NP_001274071.1  tumor protein D52 isoform 5

    See identical proteins and their annotated locations for NP_001274071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (5, also known as PrLZ-238) that is shorter than isoform 4.
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DC383362, GQ499325, U18914
    Consensus CDS
    CCDS75757.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000410222.2, ENST00000448733.3
    Conserved Domains (1) summary
    pfam04201
    Location:52 → 224
    TPD52; Tumour protein D52 family

  5. NM_001287143.2 → NP_001274072.1  tumor protein D52 isoform 6

    See identical proteins and their annotated locations for NP_001274072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (6, also known as PrLZ-233) that is shorter than isoform 4.
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DC383362, GQ499326, U18914
    Consensus CDS
    CCDS75758.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000429351.1, ENST00000517427.5
    Conserved Domains (1) summary
    pfam04201
    Location:52 → 219
    TPD52; Tumour protein D52 family

  6. NM_001287144.2 → NP_001274073.1  tumor protein D52 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, it lacks two alternate in-frame exons in the central coding region, and it uses an alternate splice site that results in an early stop codon, compared to variant 4. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    BU071387, CB128067, DA079836, DA409017, DC331087, U18914
    UniProtKB/Swiss-Prot
    P55327
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 145
    TPD52; Tumour protein D52 family

  7. NM_001387779.1 → NP_001374708.1  tumor protein D52 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC009686
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 146
    TPD52; tumor protein D52 family

  8. NM_001387780.1 → NP_001374709.1  tumor protein D52 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC009686
    Conserved Domains (1) summary
    pfam04201
    Location:20 → 154
    TPD52; tumor protein D52 family

  9. NM_005079.4 → NP_005070.1  tumor protein D52 isoform 3

    See identical proteins and their annotated locations for NP_005070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, and it lacks two alternate in-frame exons in the central coding region, compared to variant 4. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DC331087, U18914
    Consensus CDS
    CCDS55249.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000368390.4, ENST00000379096.9
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 170
    TPD52; tumor protein D52 family

RNA

  1. NR_105033.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes an additional exon in the central region, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DC383362, GQ499328, U18914

  2. NR_105034.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate 5' terminal exon and lacks three internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DB505575, DC331087, U18914

  3. NR_105035.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DA199944, DC331087, U18914

  4. NR_105036.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) contains an alternate 5' terminal exon, compared to variant 4. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC009686, AK308983, BU071387, CB128067, DA079836, DA665049, U18914

  5. NR_105037.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because it lacks a supported open reading frame.
    Source sequence(s)
    AC009686, BU071387, CB128067, DA079836, DA665049, DA921955, U18914

  6. NR_170693.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009686

  7. NR_170694.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009686

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    80031082..80171564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    80462421..80603125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55327.2 GenPept UniProtKB/Swiss-Prot:P55327

Gene LinkOut

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