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c4b complement C4B (Chido/Rodgers blood group) [ Thunnus albacares (yellowfin tuna) ]

Gene ID: 122987732, updated on 22-Mar-2024

Summary

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Gene symbol
c4b
Gene description
complement C4B (Chido/Rodgers blood group)
See related
EnsemblRapid:ENSTABG00005002965
Gene type
protein coding
RefSeq status
MODEL
Organism
Thunnus albacares
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Pelagiaria; Scombriformes; Scombridae; Thunnus
Orthologs
zebrafish all
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Genomic context

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See c4b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
42
Annotation release Status Assembly Chr Location
100 current fThuAlb1.1 (GCF_914725855.1) 8 NC_058113.1 (16463287..16480262, complement)

Chromosome 8 - NC_058113.1Genomic Context describing neighboring genes Neighboring gene steroid 21-hydroxylase Neighboring gene tenascin XBa Neighboring gene macrophage mannose receptor 1 Neighboring gene retinoid x receptor, beta b

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_058113.1 Chromosome 8 Reference fThuAlb1.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substitutions in the Glycogenin-1 Gene Are Associated with the Evolution of Endothermy in Sharks and Tunas. Ciezarek AG, et al. Genome Biol Evol, 2016 Oct 5. PMID 27614233, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C4-B
Names
complement 4B (Chido blood group)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Thunnus albacares Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fThuAlb1.1

Genomic

  1. NC_058113.1 Reference fThuAlb1.1

    Range
    16463287..16480262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044359749.1 → XP_044215684.1  complement C4-B

    Related
    ENSTABP00005006592.1, ENSTABT00005006702.1
    Conserved Domains (4) summary
    COG2373
    Location:133 → 268
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd00017
    Location:666 → 736
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:983 → 1290
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cl02512
    Location:1554 → 1706
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

  2. XM_044359748.1 → XP_044215683.1  complement C4-B

    Conserved Domains (4) summary
    COG2373
    Location:133 → 268
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd00017
    Location:666 → 736
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:983 → 1290
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cl02512
    Location:1554 → 1706
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
Nucleotide Protein
Heading Accession and Version

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