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Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 [ Mus musculus (house mouse) ]

Gene ID: 110895, updated on 2-Nov-2024

Summary

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Official Symbol
Slc9a4provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 4provided by MGI
Primary source
MGI:MGI:105074
See related
Ensembl:ENSMUSG00000026065 AllianceGenome:MGI:105074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NHE4; D730009J23Rik
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Involved in transepithelial ammonium transport. Acts upstream of or within gastric acid secretion and glandular epithelial cell development. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and thymus. Orthologous to human SLC9A4 (solute carrier family 9 member A4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 9.5), bladder adult (RPKM 2.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Slc9a4 in Genome Data Viewer
Location:
1 B; 1 19.51 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40619146..40670188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40579986..40630731)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein Neighboring gene predicted gene, 35801 Neighboring gene predicted gene, 37435 Neighboring gene STARR-seq mESC enhancer starr_00742 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 2 Neighboring gene predicted gene, 37915 Neighboring gene major facilitator superfamily domain containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. More actors in ammonia absorption by the thick ascending limb. Houillier P, et al. Am J Physiol Renal Physiol, 2012 Feb 1. PMID 22088435
  2. NHE4 is critical for the renal handling of ammonia in rodents. Bourgeois S, et al. J Clin Invest, 2010 Jun. PMID 20484819, Free PMC Article
  3. SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake. Sakuta H, et al. Pflugers Arch, 2020 May. PMID 32372285
  4. Expression, immunolocalization, and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium. Wang XF, et al. Biol Reprod, 2003 Jan. PMID 12493726
  5. Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. Gawenis LR, et al. J Biol Chem, 2005 Apr 1. PMID 15684419

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake.
    Title: SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake.
  2. Disruption of murine NHE4 leads to metabolic acidosis with inappropriate urinary ammonia excretion and decreases the ability of the thick ascending limb to absorb ammonia and to build the corticopapillary ammonia gradient.
    Title: More actors in ammonia absorption by the thick ascending limb.
  3. Dra is the major Cl(-)/HCO(3)(-) exchanger coupled with Nhe3 for electroneutral NaCl absorption across mammalian small intestine.
    Title: Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.
  4. the mRNAs of different NHE isoforms as well as their subcellular localization (apical versus basolateral) and functional activity were investigated in mouse endometrial epithelial cells
    Title: Expression, immunolocalization, and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium.
  5. NHE4, which may normally be coupled with the AE2 Cl-/HCO3- exchanger, is important for normal levels of gastric acid secretion, gastric epithelial cell differentiation, and development of secretory canalicular and tubulovesicular membranes
    Title: Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glandular epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transepithelial ammonium transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium/hydrogen exchanger 4
Names
NHE-4
Na(+)/H(+) exchanger 4
solute carrier family 9 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177084.4 → NP_796058.1  sodium/hydrogen exchanger 4 precursor

    See identical proteins and their annotated locations for NP_796058.1

    Status: VALIDATED

    Source sequence(s)
    AC138210
    Consensus CDS
    CCDS14913.1
    UniProtKB/Swiss-Prot
    Q3TCU9, Q8BUE1, Q9WUJ6
    Related
    ENSMUSP00000027233.8, ENSMUST00000027233.9
    Conserved Domains (3) summary
    TIGR00840
    Location:63 → 621
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:73 → 476
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:569 → 667
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40619146..40670188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495625.3 → XP_006495688.1  sodium/hydrogen exchanger 4 isoform X1

    Conserved Domains (1) summary
    TIGR00840
    Location:63 → 514
    b_cpa1; sodium/hydrogen exchanger 3

  2. XM_006495626.4 → XP_006495689.1  sodium/hydrogen exchanger 4 isoform X2

    Conserved Domains (1) summary
    TIGR00840
    Location:63 → 621
    b_cpa1; sodium/hydrogen exchanger 3

  3. XM_036153266.1 → XP_036009159.1  sodium/hydrogen exchanger 4 isoform X3

    Conserved Domains (1) summary
    TIGR00840
    Location:63 → 399
    b_cpa1; sodium/hydrogen exchanger 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUE1.1 GenPept UniProtKB/Swiss-Prot:Q8BUE1

Gene LinkOut

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