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Conserved domains on  [gi|45238583|ref|NP_796058|]
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sodium/hydrogen exchanger 4 precursor [Mus musculus]

Protein Classification

sodium/hydrogen exchanger( domain architecture ID 11489762)

sodium/hydrogen exchanger is a solute carrier family 9 member involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
63-621 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 883.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583    63 DYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLES 142
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASPHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   143 GYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNE 222
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   223 QLYMMIFGEALLNDGISVVLYNILIAFTKMHkFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIE 302
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHKTA-DEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   303 PLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWN 382
Cdd:TIGR00840 240 PLFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   383 WAFICFTLLFCQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKKLFVTATLVVTYF 462
Cdd:TIGR00840 320 WAFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFF 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   463 TVFFQGITIGPLVRYLDVRKTNK-KESINEELHSRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKS 541
Cdd:TIGR00840 400 TVIFQGGTIKPLVEVLKVKKGCIsKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPKS 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   542 S-IVSLYKKLEMKQAIEMVETGILSSVAS-PTPYQSERIqgIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQT 619
Cdd:TIGR00840 480 SdIVAVYHKLNLKQAISLVEGGSLSFVGTnPEPSNSEPI--IPALSSEDKEEIRDILGTNLYKPRQRFQSYSRHVLKPVP 557

                  ..
gi 45238583   620 SE 621
Cdd:TIGR00840 558 LE 559
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
63-621 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 883.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583    63 DYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLES 142
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASPHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   143 GYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNE 222
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   223 QLYMMIFGEALLNDGISVVLYNILIAFTKMHkFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIE 302
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHKTA-DEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   303 PLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWN 382
Cdd:TIGR00840 240 PLFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   383 WAFICFTLLFCQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKKLFVTATLVVTYF 462
Cdd:TIGR00840 320 WAFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFF 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   463 TVFFQGITIGPLVRYLDVRKTNK-KESINEELHSRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKS 541
Cdd:TIGR00840 400 TVIFQGGTIKPLVEVLKVKKGCIsKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPKS 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   542 S-IVSLYKKLEMKQAIEMVETGILSSVAS-PTPYQSERIqgIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQT 619
Cdd:TIGR00840 480 SdIVAVYHKLNLKQAISLVEGGSLSFVGTnPEPSNSEPI--IPALSSEDKEEIRDILGTNLYKPRQRFQSYSRHVLKPVP 557

                  ..
gi 45238583   620 SE 621
Cdd:TIGR00840 558 LE 559
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
73-476 5.30e-90

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 288.38  E-value: 5.30e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583    73 VTLWILLASLAKIgfhLYHRLPhlMPESCLLIIVGALVGGIIFGTHHKSPpvMDSSIYFLYLLPPIVLESGYFMPTRPFF 152
Cdd:pfam00999   1 IVLLILLALLAPL---LARRLK--LPPIVGLIIAGILLGPSGLGLISEVD--EDLEVLSNLGLPPLLFLAGLELDLRELR 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   153 ENIGSILWWAGLGALINAFGIGLSLYFIcqikafgLGDINLLHNLLFGSLISAVDPVAVLAVFEEA-RVNEQLYMMIFGE 231
Cdd:pfam00999  74 KNGGSILLLALLGVLIPFVLIGLLLYLL-------GLGIPLLEALLFGAILSATSPVVVLAILKELgRVPERLGTLLLGE 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   232 ALLNDGISVVLYNILIAFTKMHkfedIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSY 311
Cdd:pfam00999 147 SVLNDGVAVVLLAVLLALAQGV----GGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLAL 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   312 LSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSyttIKYFMKmlsSVSETLIFIFMGVST-IGKNHEWNWAFICFTL 390
Cdd:pfam00999 223 LAALLAEALGVSGILGAFLAGLVLSEYPFANKLSEK---LEPFGY---GLFNPLFFVLVGLSLdLSSLLLSVWILVLLAL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   391 LFCQIWRAISVFTLFYVsnqfrtFPFSIKDQFIIFYSGV-RGAGSFSLAFLLPLSLFPRKKLFvTATLVVTYFTVFFQGI 469
Cdd:pfam00999 297 VAILLGRFLGVFLLLRL------LGLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIARELY-PLLIVVVLFTVLVQGI 369

                  ....*..
gi 45238583   470 TIGPLVR 476
Cdd:pfam00999 370 TLKPLLF 376
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
70-499 6.67e-64

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 222.53  E-value: 6.67e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  70 PYEVTLWILLASLAKIGFHLYHRLPHLMpescLLIIVGALVGgiiFGTHHKSPPVMDSSIYFLYL-LPPIVLESGYFMPT 148
Cdd:COG0025   3 LLLLILLLLLLGLLSQWLARRLKLPAPL----LLLLAGILLG---PGLGLELDPELGDLEPLLELfLPPLLFEAALNLDL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 149 RPFFENIGSILWWAGLGALINAFGIGLSLYFicqikafgLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMI 228
Cdd:COG0025  76 RELRRNGRPILRLAVVGVLLTTLAVALAAHW--------LLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTIL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 229 FGEALLNDGISVVLYNILIAFTKMHKFEDIEAVdilagcARFVIVGCGGVFFGIIFGFISAFITRFTQNiSAIEPLIVFM 308
Cdd:COG0025 148 EGESLLNDATALVLFVLALAAALGGGFSLGEAL------LDFLLAILGGILVGLLLGWLLGRLLRRLPD-PLLEILLTLA 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 309 FSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVS-TIGKNHEWNWAFIC 387
Cdd:COG0025 221 LPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQlPLILLGALGLGGIL 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 388 FTLLFCQIWRAISVFtlfyVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSL---FPRKKLFVTATLVVTYFTV 464
Cdd:COG0025 301 LVLLALLVVRPLWVF----LSLALRGSRLSWRERLFLSWGGPRGIVSLALALSLPLHGgagFPGRDLILALAFGVILLTL 376
                       410       420       430
                ....*....|....*....|....*....|....*
gi 45238583 465 FFQGITIGPLVRYLDVRKTNKKEsinEELHSRLMD 499
Cdd:COG0025 377 VLQGLTLPPLARRLGLREDEPEG---EELEAALAR 408
PRK05326 PRK05326
potassium/proton antiporter;
162-546 1.70e-06

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 51.35  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  162 AGLGALINAFGIGLSLYFIcqikaFGLgdiNLLHNLLFGSLISAVDPVAVLAVFEE--ARVNEQLYMMIFGEALLNDGIS 239
Cdd:PRK05326  94 ATLGVLITAGLTGLFAHWL-----LGL---DWLEGLLLGAIVGSTDAAAVFSLLRGkgLNLKERVASTLEIESGSNDPMA 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  240 VVLYNILIAFTKMHKFEDIEAVDILagcarFVIVGCGGVFFGIIFGFISAF-ITRFTQNISAIEPLIVFMFSYLSYLAAE 318
Cdd:PRK05326 166 VFLTITLIELITGGETGLSWGFLLL-----FLQQFGLGALIGLLGGWLLVQlLNRIALPAEGLYPILVLAGALLIFALTA 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  319 TLYLSGILAITACAVTMkkyveENVSQTSYTTIKYFMKMLSSVSETLIFIFMGV----STIGknHEWNWAFIC-FTLLFc 393
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVL-----GNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLlvtpSRLL--DIALPALLLaLFLIL- 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  394 qIWRAISVF--TLFyvsnqfrtFPFSIKDQFIIFYSGVRGAGSFSLAfLLPLSL-FPRKKLFVTATLVVTYFTVFFQGIT 470
Cdd:PRK05326 313 -VARPLAVFlsLLP--------FRFNLREKLFISWVGLRGAVPIVLA-TFPMMAgLPNAQLIFNVVFFVVLVSLLLQGTT 382
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  471 IGPLVRYLDVRKTNKKESIN-------EELHSRLMDhlkagiedvcgqwshYQVRDkfkkfDHRYLRKILIRRNLPKSSI 543
Cdd:PRK05326 383 LPWAARKLGVVVPPEARPVSrveldplEESDAELLE---------------YRVPA-----GSWLVGKALRDLRLPRGAL 442

                 ...
gi 45238583  544 VSL 546
Cdd:PRK05326 443 IAL 445
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
276-392 3.29e-03

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 40.74  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 276 GGVFFGIIFGFISAFITR------FTQNISAIEPLIVFMFSYLSYLAAET--LYLSGILAITACAVTMKKYVE---ENVS 344
Cdd:cd17397 252 AGCVGGIIVGRFADRFGGrmklilLLLFSGATGSFLWFTLICLKLLPFSTvsLYTSCILLGVFLNGSVPLFYElavEAAY 331
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45238583 345 QTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNheW-NWAFICFTLLF 392
Cdd:cd17397 332 PVPEGITSGVLTFLNNVFGLVFLLILIIPNIGTS--WmNWCLLGSCLLS 378
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
63-621 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 883.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583    63 DYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLES 142
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASPHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   143 GYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNE 222
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   223 QLYMMIFGEALLNDGISVVLYNILIAFTKMHkFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIE 302
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHKTA-DEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   303 PLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWN 382
Cdd:TIGR00840 240 PLFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   383 WAFICFTLLFCQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKKLFVTATLVVTYF 462
Cdd:TIGR00840 320 WAFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFF 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   463 TVFFQGITIGPLVRYLDVRKTNK-KESINEELHSRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKS 541
Cdd:TIGR00840 400 TVIFQGGTIKPLVEVLKVKKGCIsKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPKS 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   542 S-IVSLYKKLEMKQAIEMVETGILSSVAS-PTPYQSERIqgIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQT 619
Cdd:TIGR00840 480 SdIVAVYHKLNLKQAISLVEGGSLSFVGTnPEPSNSEPI--IPALSSEDKEEIRDILGTNLYKPRQRFQSYSRHVLKPVP 557

                  ..
gi 45238583   620 SE 621
Cdd:TIGR00840 558 LE 559
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
73-476 5.30e-90

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 288.38  E-value: 5.30e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583    73 VTLWILLASLAKIgfhLYHRLPhlMPESCLLIIVGALVGGIIFGTHHKSPpvMDSSIYFLYLLPPIVLESGYFMPTRPFF 152
Cdd:pfam00999   1 IVLLILLALLAPL---LARRLK--LPPIVGLIIAGILLGPSGLGLISEVD--EDLEVLSNLGLPPLLFLAGLELDLRELR 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   153 ENIGSILWWAGLGALINAFGIGLSLYFIcqikafgLGDINLLHNLLFGSLISAVDPVAVLAVFEEA-RVNEQLYMMIFGE 231
Cdd:pfam00999  74 KNGGSILLLALLGVLIPFVLIGLLLYLL-------GLGIPLLEALLFGAILSATSPVVVLAILKELgRVPERLGTLLLGE 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   232 ALLNDGISVVLYNILIAFTKMHkfedIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSY 311
Cdd:pfam00999 147 SVLNDGVAVVLLAVLLALAQGV----GGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLAL 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   312 LSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSyttIKYFMKmlsSVSETLIFIFMGVST-IGKNHEWNWAFICFTL 390
Cdd:pfam00999 223 LAALLAEALGVSGILGAFLAGLVLSEYPFANKLSEK---LEPFGY---GLFNPLFFVLVGLSLdLSSLLLSVWILVLLAL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   391 LFCQIWRAISVFTLFYVsnqfrtFPFSIKDQFIIFYSGV-RGAGSFSLAFLLPLSLFPRKKLFvTATLVVTYFTVFFQGI 469
Cdd:pfam00999 297 VAILLGRFLGVFLLLRL------LGLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIARELY-PLLIVVVLFTVLVQGI 369

                  ....*..
gi 45238583   470 TIGPLVR 476
Cdd:pfam00999 370 TLKPLLF 376
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
70-499 6.67e-64

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 222.53  E-value: 6.67e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  70 PYEVTLWILLASLAKIGFHLYHRLPHLMpescLLIIVGALVGgiiFGTHHKSPPVMDSSIYFLYL-LPPIVLESGYFMPT 148
Cdd:COG0025   3 LLLLILLLLLLGLLSQWLARRLKLPAPL----LLLLAGILLG---PGLGLELDPELGDLEPLLELfLPPLLFEAALNLDL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 149 RPFFENIGSILWWAGLGALINAFGIGLSLYFicqikafgLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMI 228
Cdd:COG0025  76 RELRRNGRPILRLAVVGVLLTTLAVALAAHW--------LLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTIL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 229 FGEALLNDGISVVLYNILIAFTKMHKFEDIEAVdilagcARFVIVGCGGVFFGIIFGFISAFITRFTQNiSAIEPLIVFM 308
Cdd:COG0025 148 EGESLLNDATALVLFVLALAAALGGGFSLGEAL------LDFLLAILGGILVGLLLGWLLGRLLRRLPD-PLLEILLTLA 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 309 FSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVS-TIGKNHEWNWAFIC 387
Cdd:COG0025 221 LPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQlPLILLGALGLGGIL 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 388 FTLLFCQIWRAISVFtlfyVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSL---FPRKKLFVTATLVVTYFTV 464
Cdd:COG0025 301 LVLLALLVVRPLWVF----LSLALRGSRLSWRERLFLSWGGPRGIVSLALALSLPLHGgagFPGRDLILALAFGVILLTL 376
                       410       420       430
                ....*....|....*....|....*....|....*
gi 45238583 465 FFQGITIGPLVRYLDVRKTNKKEsinEELHSRLMD 499
Cdd:COG0025 377 VLQGLTLPPLARRLGLREDEPEG---EELEAALAR 408
NEXCaM_BD pfam16644
Regulatory region of Na+/H+ exchanger NHE binds to calmodulin; NEXCaM_BD is a coiled-coil ...
566-667 3.13e-55

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin; NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD.


Pssm-ID: 465214  Cd Length: 109  Bit Score: 185.30  E-value: 3.13e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   566 SVASPTPYQSERIQGIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGQSL 645
Cdd:pfam16644   1 AVPSTVSLQNIRKESTKRLSPADVEEMRDILSKNLYQIRQRTLSYNRHNLVADTSEKQAKEILIRRQHSLRESLRKGSSL 80
                          90       100
                  ....*....|....*....|..
gi 45238583   646 PwGKPAGTKNFRYLSFPYSNPQ 667
Cdd:pfam16644  81 P-GRPAGTKTQRYLSLPKNTSL 101
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
94-496 1.61e-41

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 159.67  E-value: 1.61e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583    94 PHLMPESCLLIIVGALVGGIIFGTHHKsppvMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGI 173
Cdd:TIGR00831  19 FIRLPYPIALILAGLLLGLAGLLPEVP----LDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   174 GLSLYFIcqikafgLGdINLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNILIAFTkmh 253
Cdd:TIGR00831  95 GFSLNWI-------LG-IPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVVFAIAVAVA--- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   254 kfEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAV 333
Cdd:TIGR00831 164 --LGKGVFDPLNAALDFAVVCVGGIAAGLAVGYLAYRLLRAKIDDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   334 TMKKY-VEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGK-NHEWN----------WA-FICFTLLFCQIWRAIS 400
Cdd:TIGR00831 242 ILTNYgRDFSMSPTTRLIALDFWSVIVFLVNGIIFILIGVQTPGTiFSAWKeilvapaaviLAlFTNAFVIYPVMTYVRF 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583   401 VFTLFYVSNQF---RTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSL-----FPRKKLFVTATLVVTYFTVFFQGITIG 472
Cdd:TIGR00831 322 LWTMKPFSNRFlkkKPMEFGTRWKHVVSWAGLRGAIPLALALSFPNQLlsgmaFPARYELVFLAAGVILFSLLVQGISLP 401
                         410       420
                  ....*....|....*....|....
gi 45238583   473 PLVRYLDVRKTNKKEsiNEELHSR 496
Cdd:TIGR00831 402 IFVKRKFVSEHSERE--LEEIIAR 423
PRK05326 PRK05326
potassium/proton antiporter;
162-546 1.70e-06

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 51.35  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  162 AGLGALINAFGIGLSLYFIcqikaFGLgdiNLLHNLLFGSLISAVDPVAVLAVFEE--ARVNEQLYMMIFGEALLNDGIS 239
Cdd:PRK05326  94 ATLGVLITAGLTGLFAHWL-----LGL---DWLEGLLLGAIVGSTDAAAVFSLLRGkgLNLKERVASTLEIESGSNDPMA 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  240 VVLYNILIAFTKMHKFEDIEAVDILagcarFVIVGCGGVFFGIIFGFISAF-ITRFTQNISAIEPLIVFMFSYLSYLAAE 318
Cdd:PRK05326 166 VFLTITLIELITGGETGLSWGFLLL-----FLQQFGLGALIGLLGGWLLVQlLNRIALPAEGLYPILVLAGALLIFALTA 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  319 TLYLSGILAITACAVTMkkyveENVSQTSYTTIKYFMKMLSSVSETLIFIFMGV----STIGknHEWNWAFIC-FTLLFc 393
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVL-----GNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLlvtpSRLL--DIALPALLLaLFLIL- 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  394 qIWRAISVF--TLFyvsnqfrtFPFSIKDQFIIFYSGVRGAGSFSLAfLLPLSL-FPRKKLFVTATLVVTYFTVFFQGIT 470
Cdd:PRK05326 313 -VARPLAVFlsLLP--------FRFNLREKLFISWVGLRGAVPIVLA-TFPMMAgLPNAQLIFNVVFFVVLVSLLLQGTT 382
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  471 IGPLVRYLDVRKTNKKESIN-------EELHSRLMDhlkagiedvcgqwshYQVRDkfkkfDHRYLRKILIRRNLPKSSI 543
Cdd:PRK05326 383 LPWAARKLGVVVPPEARPVSrveldplEESDAELLE---------------YRVPA-----GSWLVGKALRDLRLPRGAL 442

                 ...
gi 45238583  544 VSL 546
Cdd:PRK05326 443 IAL 445
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
72-327 3.49e-04

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 43.60  E-value: 3.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583  72 EVTLWILLASLAKIGFHLYhRLPHlmpesclliIVGALVGGIIFGTHHKSPPVMDSSIYFL------YLLppivLESGYF 145
Cdd:COG0475   8 QLGLLLLAAVLAGLLARRL-GLPS---------VLGYILAGILLGPSGLGLIEDSEALELLaelgvvLLL----FLIGLE 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 146 MPTRPFFENIGSILWWAGLGALINAFGIGLSLYFicqikaFGLGdinLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLY 225
Cdd:COG0475  74 LDLKRLRKMGRRALGIGLLQVLLPFLLGFLLALL------LGLS---LAAALFLGAALAATSTAIVLKVLKELGLLKTPL 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 226 -MMIFGEALLNDGISVVLYNILIAFTKmhkfedieAVDILAGCARFVIVGCGGVFFGIIFG-FISAFITRFTQNISAIEP 303
Cdd:COG0475 145 gQLILGVALFDDIAAILLLALVPALAG--------GGSVAGSLLLALLKALLFLALLLLVGrYLLRRLFRLVARTRSREL 216
                       250       260       270
                ....*....|....*....|....*....|
gi 45238583 304 ------LIVFMFSYLsylaAETLYLSGILA 327
Cdd:COG0475 217 fllfalLLVLLAAAL----AELLGLSAALG 242
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
276-392 3.29e-03

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 40.74  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238583 276 GGVFFGIIFGFISAFITR------FTQNISAIEPLIVFMFSYLSYLAAET--LYLSGILAITACAVTMKKYVE---ENVS 344
Cdd:cd17397 252 AGCVGGIIVGRFADRFGGrmklilLLLFSGATGSFLWFTLICLKLLPFSTvsLYTSCILLGVFLNGSVPLFYElavEAAY 331
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45238583 345 QTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNheW-NWAFICFTLLF 392
Cdd:cd17397 332 PVPEGITSGVLTFLNNVFGLVFLLILIIPNIGTS--WmNWCLLGSCLLS 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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