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SLU7 SLU7 homolog, splicing factor [ Homo sapiens (human) ]

Gene ID: 10569, updated on 3-Apr-2024

Summary

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Official Symbol
SLU7provided by HGNC
Official Full Name
SLU7 homolog, splicing factorprovided by HGNC
Primary source
HGNC:HGNC:16939
See related
Ensembl:ENSG00000164609 MIM:605974; AllianceGenome:HGNC:16939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
9G8; hSlu7
Summary
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q33.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160401641..160419081, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160930130..160947593, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159828648..159846088, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159825203-159825702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159826022-159826707 Neighboring gene family with sequence similarity 200 member C Neighboring gene MPRA-validated peak5561 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159849111-159849667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23564 Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159894202-159894838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159894839-159895475 Neighboring gene MIR3142 host gene Neighboring gene microRNA 3142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease. Gárate-Rascón M, et al. Int J Mol Sci, 2022 Nov 2. PMID 36362191, Free PMC Article
  2. Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice. Wang J, et al. Am J Pathol, 2018 Aug. PMID 29870742, Free PMC Article
  3. Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression. Urtasun R, et al. Oncogene, 2016 Sep 8. PMID 26804174
  4. Splicing regulator SLU7 is essential for maintaining liver homeostasis. Elizalde M, et al. J Clin Invest, 2014 Jul. PMID 24865429, Free PMC Article
  5. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. Shomron N, et al. J Cell Sci, 2005 Mar 15. PMID 15728250

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.
    Title: SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.
  2. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
    Title: Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
  3. The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation.
    Title: The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation.
  4. We define a molecular pathway through which SLU7 keeps in check the generation of truncated forms of the splicing factor SRSF3 (SRp20) (SRSF3-TR). Behaving as dominant negative, or by gain-of-function, SRSF3-TR impair the correct splicing and expression of the splicing regulator SRSF1 (ASF/SF2) and the crucial SCC protein sororin.
    Title: Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins.
  5. High SLU7 expression is associated with alcoholic steatohepatitis.
    Title: Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
  6. these findings indicate that SLU7 is co-opted by hepatocellular carcinoma (HCC) cells and other tumor cell types to maintain survival, and identify this splicing regulator as a new determinant for the expression of the oncogenic miR-17-92 cluster. This novel mechanism may be exploited for the development of antitumoral strategies in cancers displaying such SLU7-miR-17-92 crosstalk
    Title: Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.
  7. SLU7 knockdown in liver cells resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern.
    Title: Splicing regulator SLU7 is essential for maintaining liver homeostasis.
  8. These observations together point to an altered recruitment and dependence on SLU7, suggesting its role in facilitating transitions that promote catalysis, and highlight the diversity in spliceosome assembly.
    Title: Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.
  9. RBM22 and hSlu7 differ significantly in their subcellular distributions under stress conditions, and RBM22 enhances the cytoplasmic translocation of hSlu7 under stress.
    Title: Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7.
  10. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing
    Title: Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of SLU7 splicing factor homolog (SLU7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables pre-mRNA 3'-splice site binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables second spliceosomal transesterification activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing, via transesterification reactions IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA 3'-splice site recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small nuclear ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pre-mRNA-splicing factor SLU7
Names
SLU7 splicing factor homolog
splicing factor
step II splicing factor SLU7
zinc knuckle motif containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364517.2 → NP_001351446.1  pre-mRNA-splicing factor SLU7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC091842
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:176 → 449
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  2. NM_001364518.2 → NP_001351447.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC091842
    Consensus CDS
    CCDS4352.1
    UniProtKB/Swiss-Prot
    D3DQK2, O95391, Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  3. NM_001364520.2 → NP_001351449.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
    Source sequence(s)
    AC091842
    Consensus CDS
    CCDS4352.1
    UniProtKB/Swiss-Prot
    D3DQK2, O95391, Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  4. NM_001364521.2 → NP_001351450.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
    Source sequence(s)
    AC091842
    Consensus CDS
    CCDS4352.1
    UniProtKB/Swiss-Prot
    D3DQK2, O95391, Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  5. NM_001364522.2 → NP_001351451.1  pre-mRNA-splicing factor SLU7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AC091842
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:171 → 444
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  6. NM_001364523.2 → NP_001351452.1  pre-mRNA-splicing factor SLU7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AC091842
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:171 → 444
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  7. NM_006425.5 → NP_006416.3  pre-mRNA-splicing factor SLU7 isoform b

    See identical proteins and their annotated locations for NP_006416.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
    Source sequence(s)
    AC091842, BC010634, BE221264, CA976106, DA232975, DA409854
    Consensus CDS
    CCDS4352.1
    UniProtKB/Swiss-Prot
    D3DQK2, O95391, Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9
    UniProtKB/TrEMBL
    B2RBA0
    Related
    ENSP00000297151.4, ENST00000297151.9
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    160401641..160419081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454327.2 → XP_024310095.1  pre-mRNA-splicing factor SLU7 isoform X1

    UniProtKB/Swiss-Prot
    D3DQK2, O95391, Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9
    UniProtKB/TrEMBL
    B2RBA0
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    160930130..160947593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351441.1 → XP_054207416.1  pre-mRNA-splicing factor SLU7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95391.2 GenPept UniProtKB/Swiss-Prot:O95391

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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