AGO2 argonaute 2, RISC catalytic component [Gallus gallus (chicken)] - Gene

Summary

Symbol: AGO2provided by CGNC
Full Name: argonaute 2, RISC catalytic componentprovided by CGNC
Primary source: CGNC:64972
See related: Ensembl:ENSGALG00010009068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (144560659..144615845, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (144931721..144987129, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables endoribonuclease activity, cleaving siRNA-paired mRNA	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein argonaute-2

Names: argonaute RISC catalytic component 2

NP_001376478.1

EC 3.1.26.n2

XP_040529398.1

EC 3.1.26.n2

XP_046766076.1

EC 3.1.26.n2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389549.2 → NP_001376478.1 protein argonaute-2

Status: VALIDATED

Source sequence(s)

JAENSK010000044

UniProtKB/TrEMBL

A0A8V0Y222, A0A8V0Y8M7

Related

ENSGALP00010012370.1, ENSGALT00010021680.1

Conserved Domains (4) summary

cd02846
Location:231 → 351

PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...

cd04657
Location:396 → 821

Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

pfam08699
Location:180 → 230

ArgoL1; Argonaute linker 1 domain

pfam16486
Location:96 → 170

ArgoN; N-terminal domain of argonaute

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

144560659..144615845 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040673464.2 → XP_040529398.1 protein argonaute-2 isoform X1

UniProtKB/TrEMBL

A0A8V0Y8M7

Related

ENSGALP00010012387.1, ENSGALT00010021700.1

Conserved Domains (4) summary

cd02846
Location:232 → 352

PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...

cd04657
Location:397 → 822

Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

pfam08699
Location:181 → 231

ArgoL1; Argonaute linker 1 domain

pfam16486
Location:96 → 171

ArgoN; N-terminal domain of argonaute

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

144931721..144987129 complement

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GenBank, FASTA, Sequence Viewer (Graphics)