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Paep progestagen associated endometrial protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 100169711, updated on 2-Nov-2024

Summary

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Official Symbol
Paepprovided by RGD
Official Full Name
progestagen associated endometrial proteinprovided by RGD
Primary source
RGD:2293817
See related
EnsemblRapid:ENSRNOG00000073207 AllianceGenome:RGD:2293817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lcn11
Summary
Predicted to enable small molecule binding activity. Predicted to be involved in several processes, including negative regulation of sperm capacitation; positive regulation of granulocyte macrophage colony-stimulating factor production; and regulation of binding activity of sperm to zona pellucida. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human PAEP (progestagen associated endometrial protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 1.8), Uterus (RPKM 1.8) and 4 other tissues See more
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Genomic context

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See Paep in Genome Data Viewer
Location:
3p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28929252..28932592, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8531136..8534430, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2935396..2938883, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene brain expressed myelocytomatosis oncogene Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 5 Neighboring gene progestagen associated endometrial protein like 1 Neighboring gene lipocalin 3 Neighboring gene von Ebner gland protein 1-like Neighboring gene odorant binding protein 2B like 1 Neighboring gene odorant binding protein 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the oligomerization and ligand-binding properties of recombinant rat lipocalin 11. Gu Y, et al. Biochim Biophys Acta, 2013 Jan. PMID 23451353
  2. Glycodelin-A modulates cytokine production of peripheral blood natural killer cells. Lee CL, et al. Fertil Steril, 2010 Jul. PMID 19945098
  3. Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. Alok A, et al. Int J Biochem Cell Biol, 2009 May. PMID 18996219
  4. Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding. Chiu PC, et al. J Biol Chem, 2007 Feb 23. PMID 17192260
  5. Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa. Chiu PC, et al. J Biol Chem, 2005 Jul 8. PMID 15883155

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sperm capacitation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
progestagen associated endometrial protein
Names
lipocalin 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135809.1 → NP_001129281.1  progestagen associated endometrial protein precursor

    See identical proteins and their annotated locations for NP_001129281.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ537495
    UniProtKB/TrEMBL
    B3EY86
    Related
    ENSRNOP00000075567.1, ENSRNOT00000084196.3
    Conserved Domains (1) summary
    pfam00061
    Location:35 → 145
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28929252..28932592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282942.1 → XP_063139012.1  progestagen associated endometrial protein isoform X2

  2. XM_063282941.1 → XP_063139011.1  progestagen associated endometrial protein isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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