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erap2 endoplasmic reticulum aminopeptidase 2 [ Danio rerio (zebrafish) ]

Gene ID: 100144556, updated on 12-Sep-2024

Summary

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Official Symbol
erap2provided by ZNC
Official Full Name
endoplasmic reticulum aminopeptidase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-080402-6
See related
Ensembl:ENSDARG00000098618 AllianceGenome:ZFIN:ZDB-GENE-080402-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:172163
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ERAP2 (endoplasmic reticulum aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See erap2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (52222737..52244668, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (51580166..51598067, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 14 member 2 Neighboring gene leucyl/cystinyl aminopeptidase Neighboring gene repulsive guidance molecule BMP co-receptor b Neighboring gene transfer RNA proline (anticodon UGG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos. Martínez R, et al. Sci Total Environ, 2019 Jul 15. PMID 31022537
  2. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Gao Y, et al. Vaccine, 2014 Oct 14. PMID 25219565
  3. Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish. Yang D, et al. Dev Comp Immunol, 2013 Jun. PMID 23434462
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endoplasmic reticulum aminopeptidase 2
NP_001116524.1
XP_005165525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123052.1 → NP_001116524.1  endoplasmic reticulum aminopeptidase 2 precursor

    See identical proteins and their annotated locations for NP_001116524.1

    Status: PROVISIONAL

    Source sequence(s)
    BC160625
    UniProtKB/TrEMBL
    B1H1J0
    Related
    ENSDARP00000136067.2, ENSDART00000159078.3
    Conserved Domains (3) summary
    cd09601
    Location:52 → 522
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:44 → 432
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:595 → 911
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    52222737..52244668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165468.4 → XP_005165525.1  endoplasmic reticulum aminopeptidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCU9
    Conserved Domains (3) summary
    cd09601
    Location:52 → 522
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:44 → 432
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:595 → 911
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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