4FYS,4NZ8


Conserved Protein Domain Family
ERAP1_C
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pfam11838: ERAP1_C (this model, PSSM-Id:288671 is obsolete and has been replaced by 463368)
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ERAP1-like C-terminal domain
This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.
Links
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Statistics
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PSSM-Id: 288671
Aligned: 793 rows
Threshold Bit Score: 32.3259
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4FYS_A       556 VLLNLN--VTGYYRVNY-DEENWRKIqtqlqrdhsaIP-----VIN---RAQIINDAfnLASAHKVPVtLAL---NNTLF 621  human
A0D4H7       530 VLLNFD--DGSFVKTSYsQQQADFFL----------KNlsnlsTIN---RVLVLRSIwdQVRDGLTGFt------TFING 588  Paramecium tet...
A0CQU5       614 LLLNYE--DQSFVKVLL-DQESTKYF-----------SqnlqaVQDiltRTLIYRALfdSVRDGKISSe------EYVDF 673  Paramecium tet...
Q24I41       629 VLLNYA--DQGYIKINF-DDVSFNFF-----------KknvckINDiltRTLIWGVFydLVRDGKISSe------EFVEI 688  Tetrahymena th...
XP_001023990 575 VLLNYG--DWGFIKVLL-DDISIEFF-----------KlnlhkITDivtRTLIWRAFfdMVRDGKLSSe------EYIDI 634  Tetrahymena th...
XP_004029730 573 VLLNYQ--DFAFIKVLL-DDLSIVFF-----------KnnmhkIKDvltRNLIWRAFfdMVRDGKLSSe------EYFDI 632  Ichthyophthiri...
XP_001023080 566 VLLNYG--DYAFIKTIL-DPVSLTFL-----------QhnlhkISDvltRTLIWKAFydMARDGKISSe------QYVDI 625  Tetrahymena th...
WP_015817349 569 VYPNYE--EWGYVKLAL-DEISMATL----------MQtgiggFSDehmRSAIWQILgdMVNSLRLPLt------DYVNF 629  Teredinibacter...
WP_011754382 507 VVPNSH--GETFARIVL-DRRSRDKL----------AGglcriDDDl-vRAVLWTMLfdEVQARALPAaEYV---DLVQQ 569  Nocardioides s...
WP_012390335 545 VFINAEdhDFAIWSWTSvNKDNLEFV----------LEfd-ndPMR---KLILWTDYfrQVSLANLSF-DEFketAIRLY 609  Leptospira bif...

4FYS_A       622 -Li---eERQ---YM---------P--WEA---ALsslsyfklmfdrsevygpmknylkkqvtplfihfrnntnnwreip 680  human
A0D4H7       589 vLksllnETDdavLQmvlewctggVsfYCPikhRQtfenelahviie-----------------------------llrk 639  Paramecium tet...
A0CQU5       674 lLaqlprENSdeiLNtqllylqsaIasMTPrkfKKilgkrvftflleqii-----------------------kvskdpq 730  Paramecium tet...
Q24I41       689 fIenipnEQSediITnqvenitqlYsqYTPekyKLalgerifnfllmyl-------------------------lsipkd 743  Tetrahymena th...
XP_001023990 635 fInaipnETSddiITsqlqylqgaYssFTPeqyKLvlgervfnfllkyl-------------------------lsipae 689  Tetrahymena th...
XP_004029730 633 fMtaiphEQSddiITnqlmflnsaYsqFTPrkyQNqlaarmfnflvsyl-------------------------lkipke 687  Ichthyophthiri...
XP_001023080 626 fIsciknEVSeeiVApqftylsniVslFTPlkyKSilkqklfsfcynfl-------------------------lstske 680  Tetrahymena th...
WP_015817349 630 iVanlpaETS-----------------VDNltfLMepathafndleam---------------------------ppsda 665  Teredinibacter...
WP_011754382 570 hLage-----------------rsAvlVSA---VLartl----------------------------------------- 588  Nocardioides s...
WP_012390335 610 pM-----ETD---TK---------IkrW-----LLsrltsdtgssyftsr-----------------------fwfpesk 644  Leptospira bif...

4FYS_A       681 enlmdqysEVNAisTAC-SNGVP----------------------------ECEEMv-sGlfkqwme---npnnnpIHPN 727  human
A0D4H7       640 cpkenknkRLILldYLAlWGTSQqnlefllqhinsddaefgfiglsngwriIRNIFanlN----------------IPKE 703  Paramecium tet...
A0CQU5       731 qenklillRNNMaaFAYdNTCVDellawfqgq------------------------------------nqelssieCTKD 774  Paramecium tet...
Q24I41       744 nknriicvRDSLdsFARsEVHIIklvnwlkke------------------------------------dqdlkhieIGLA 787  Tetrahymena th...
XP_001023990 690 nknriiavRDKLdgFARsDAHIAkllawyngt------------------------------------dedlknieVGLS 733  Tetrahymena th...
XP_004029730 688 nknriieiKDKLdfFARnNEHIVylldwyngn------------------------------------nqdlkdfeLGNS 731  Ichthyophthiri...
XP_001023080 681 qknkiitiKTALiqYADsQEQISslvqwfkgq------------------------------------nkelegfeIGNE 724  Tetrahymena th...
WP_015817349 666 sraalaalETVAwsQFNtAPEDSlrrralfelvtvtthtserldalknliaARPPArgaL----------------TVQW 729  Teredinibacter...
WP_011754382 589 -----drvLPLRtpAAAaAGAHDaiasacetglmhaatpalalafasgfaaTTREGatlRgwleag----tvgdlpLPPT 659  Nocardioides s...
WP_012390335 645 rnnhldslQNFIlsELTkAKAGSdeqkyl----------------flslidSSFTEssqkrlyeilenklsfpglkLDQD 708  Leptospira bif...

4FYS_A       728 LRSTVyCNAiaqg-------------geeeWDFAWEQF----RnaTlvneADKLRAALA-CSKElwiLNRy---LSYTln 786  human
A0D4H7       704 QKWQLfEKWaqrdgtdevrlqkrflenlfnFDKLWDYFinynKeeS----IPMVREAMA--------AFNhkiyLEQLqt 771  Paramecium tet...
A0CQU5       775 TKWAIvKLVyasqkydsn--------pelrkeileKMLqidtSdaA----SRAQLKCKA-LIAN---EQEraalWQKYvd 838  Paramecium tet...
Q24I41       788 LSWRIvALAhkckkytr----------eeknalfqKQKerdpSdtS----QYNQHLCKA-LDLS---PDEretlWKFYis 849  Tetrahymena th...
XP_001023990 734 VQWRIvSLVhksrkytr----------eektqlfkKQAerdpSdtS----KNYEQKCKA-LDVN---AEEreklWNFYfs 795  Tetrahymena th...
XP_004029730 732 IEWRIvSLVhkskkftr----------dqknslfnIQSqkdqTdtK----YNYEYKCKA-LDAN---QQEreqlWNSYin 793  Ichthyophthiri...
XP_001023080 725 GEWQIvCLAhqssqytl----------qekkqifdEQLkkdsSdtS----KNMEQKCRA-IVAS---AEErqvlWNQYin 786  Tetrahymena th...
WP_015817349 730 LRWQAiQQLsrydvkg-------------yqalidTELerdtSetG----RQASLLARA-IAPT---KSAkkpwVDALld 788  Teredinibacter...
WP_011754382 660 LRWRSvRRLaqtgavdaafieeerrrepglEAEHGTAAalaaRptVa--aKDEAWAAAAdPTVD---NRRfaalLDGL-- 732  Nocardioides s...
WP_012390335 709 LRWNMiVKLsslai------------drnkIQTMIDREkk-lDpsNr--gVNSSLAAEA-AEPNpkiKDKw---IQIL-- 767  Leptospira bif...

4FYS_A       787 p---------------------dliR---KQDATSTI-------ISitnN-VIGqg----lVW-DFVQs----------n 819  human
A0D4H7       772 ye---------------------------------------------------------------------------qky 776  Paramecium tet...
A0CQU5       839 pndkesakmiaesmagfnnerrylsLepyQDKf----------------------------------------------- 871  Paramecium tet...
Q24I41       850 ssnklsvknltyswsgfnstfnrtdLmpyFDKf----------------------------------------------- 882  Tetrahymena th...
XP_001023990 796 aentlsvrnleyswsgfnssfnheeLepyFEKf----------------------------------------------- 828  Tetrahymena th...
XP_004029730 794 ydgktslrriqfswsgfsqtfnpdeLepyYQKf----------------------------------------------- 826  Ichthyophthiri...
XP_001023080 787 klefsqrilqn-smegfvstkdsdlIkpyNEKf----------------------------------------------- 818  Tetrahymena th...
WP_015817349 789 pdsavt-------------------lsemravWENLY--------------PGKqramlaeTGpDILaalpaiseqreai 835  Teredinibacter...
WP_011754382     --------------------------------------------------------------------------------      Nocardioides s...
WP_012390335 768 -------------------------LnpkASDYSSSTlrvvsysLFp--EhQKGiq-------lQFLDt----------y 803  Leptospira bif...

4FYS_A       820 WK---KL-FNdygggsfsfSNLIQavtrrfS-----T------EYelqQLEQFkkd-------------------neETG 865  human
A0D4H7       777 FE----------------------------------AlptifsTKsseYAKEFyhslypindn-----insyielceKTL 817  Paramecium tet...
A0CQU5       872 FEviiqifqtk----------sndfsktfyDylfpiT------DDlasLCNKVek---------------------lRTT 914  Paramecium tet...
Q24I41       883 FGviktiidtk----------sqefaseffSyllpvT------EDfqrLIQNLeq---------------------lLSN 925  Tetrahymena th...
XP_001023990 829 FEkilhvydtk----------pkefandfyQyllpnT------EDyakLISRLes---------------------lLSN 871  Tetrahymena th...
XP_004029730 827 FDsvivihskq----------nkeyandfyQylfpvS------EDwdrLIKSLnq---------------------lKSG 869  Ichthyophthiri...
XP_001023080 819 FAdikvvyanq----------ipeyasivyDslqpqS------DDldwLIAQYtn---------------------vLSS 861  Tetrahymena th...
WP_015817349 836 FL----------------------------SklaekFipvgcrSSsvnALENA------------------------IQN 863  Teredinibacter...
WP_011754382 733 WSteqA-------------------------------------ELlapYVDRYlheapdwarrgqafaqvvgrhrpaLAL 775  Nocardioides s...
WP_012390335 804 FA---ALdKFqhtddenylDAFAKslapdfC-----T------DEtllILKKF------------------------TNN 845  Leptospira bif...

4FYS_A       866 F---GSG-TRALEQALEK 879  human
A0D4H7       818 LksqHDIlTKFLKDSIDa 835  Paramecium tetraurelia
A0CQU5       915 VpenLITlKMQVDKSLDS 932  Paramecium tetraurelia
Q24I41       926 LdedHSYfKVLIEEQLDD 943  Tetrahymena thermophila SB210
XP_001023990 872 LnekYVFlQRYIKESIDD 889  Tetrahymena thermophila SB210
XP_004029730 870 LsdkYVHlHRHINESIDD 887  Ichthyophthirius multifiliis
XP_001023080 862 VpstQVFfTRRLKETLDl 879  Tetrahymena thermophila SB210
WP_015817349 864 KseyAPAvVRALRirhqe 881  Teredinibacter turnerae
WP_011754382 776 DadqVAGlDRALAGDLPT 793  Nocardioides sp. JS614
WP_012390335 846 HpklPASvKKTLWKQIDS 863  Leptospira biflexa
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