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Mup11 major urinary protein 11 [ Mus musculus (house mouse) ]

Gene ID: 100039028, updated on 2-Nov-2024

Summary

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Official Symbol
Mup11provided by MGI
Official Full Name
major urinary protein 11provided by MGI
Primary source
MGI:MGI:3709617
See related
Ensembl:ENSMUSG00000073834 AllianceGenome:MGI:3709617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mup16; Mup18; Gm12549
Summary
Enables pheromone binding activity. Involved in cellular response to testosterone stimulus. Predicted to be located in cytosol and nucleus. Predicted to be active in extracellular space. Is expressed in reproductive system and urethra. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 2524.2) See more
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Genomic context

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See Mup11 in Genome Data Viewer
Location:
4 B3; 4 32.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (60614465..60618438, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (60658466..60662432, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene major urinary protein 10 Neighboring gene major urinary protein, pseudogene 5 Neighboring gene major urinary protein, pseudogene 7 Neighboring gene major urinary protein 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin. Phelan MM, et al. PLoS One, 2014. PMID 25279835, Free PMC Article
  2. The gene family for major urinary proteins: expression in several secretory tissues of the mouse. Shaw PH, et al. Cell, 1983 Mar. PMID 6831559
  3. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom". Charkoftaki G, et al. Hum Genomics, 2019 Feb 19. PMID 30782214, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables insulin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pheromone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pheromone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to lipid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to testosterone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in energy reserve metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heat generation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
major urinary protein 11
Names
Major urinary protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164526.1 → NP_001157998.1  major urinary protein 11 precursor

    See identical proteins and their annotated locations for NP_001157998.1

    Status: VALIDATED

    Source sequence(s)
    AI118205, AK013972, BX950196
    Consensus CDS
    CCDS51190.1
    UniProtKB/Swiss-Prot
    A2BIM8, P04938
    UniProtKB/TrEMBL
    Q9CXU6
    Related
    ENSMUSP00000095654.4, ENSMUST00000098046.10
    Conserved Domains (1) summary
    pfam00061
    Location:35 → 171
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    60614465..60618438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537483.5 → XP_006537546.1  major urinary protein 11 isoform X1

    Conserved Domains (1) summary
    cd19428
    Location:24 → 173
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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