GEO DataSets

(Submitter supplied) Hibernation is energy saving adaptation involving suppression of activity to survive in highly seasonal environments. Immobility and disuse generate muscle loss in most mammalian species. In contrast to other mammals, bears and ground squirrels demonstrate limited muscle atrophy over the physical inactivity of winter hibernation. This suggests that hibernating mammals have adaptive mechanisms to prevent disuse muscle atrophy. more...

Organism:

Urocitellus parryii

Type:

Expression profiling by array

Platform:

GPL15674

19 Samples

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(Submitter supplied) Mammalian hibernators display phenotypes similar to physiological conditions in non-hibernating species under conditions of calorie restriction and fasting, hypoxia, hypothermia, ischemia-reperfusion, and sleep. However, whether or how similarities are also reflected on molecular and genetic levels is unclear. We identified molecular signatures of torpor and arousal in hibernation using a new custom-designed cDNA microarray for the arctic ground squirrel (Urocitellus parryii,) and compared them to molecular signatures of selected phenotypes in mouse. more...

Organism:

Urocitellus parryii

Type:

Expression profiling by array

Platform:

GPL15674

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Urocitellus parryii; Mus musculus

Type:

Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL9863 GPL7732

6 Samples

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(Submitter supplied) miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cellular reorganization, during which miRNAs may play an important role. We systematically analyzed the miRNAs in the liver of an extreme hibernating species, arctic ground squirrels (Spermophilus parryii), during two stages of hibernation compared to non-hibernating animals by massively parallel Illumina sequencing technology. more...

Organism:

Urocitellus parryii

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL9863

3 Samples

Download data: TXT

(Submitter supplied) miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cellular reorganization, during which miRNAs may play an important role. We systematically analyzed the miRNAs in the liver of an extreme hibernating species, arctic ground squirrels (Spermophilus parryii), during two stages of hibernation compared to non-hibernating animals by massively parallel Illumina sequencing technology. more...

Organism:

Mus musculus; Urocitellus parryii

Type:

Non-coding RNA profiling by array

Platform:

GPL7732

3 Samples

Download data: TXT

(Submitter supplied) Differential gene expression in a wide range of tissues including brown adipose tissue (BAT), liver, heart, hypothalamus, and skeletal muscle in hibernating arctic ground squirrels during multiple stages in torpor-arousal cycles compared to non-hibernating (post-reproductive) animals with illumina beadarray technology. Keywords: Multiple stage comparison

Organism:

Ictidomys tridecemlineatus; Urocitellus parryii; Callospermophilus lateralis

Type:

Expression profiling by array

Platforms:

GPL4042 GPL4041

288 Samples

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(Submitter supplied) Hibernation is an energy-saving strategy adopted by a wide range of mammals to survive highly seasonal or unpredictable environments. Arctic ground squirrels living in Alaska provide an extreme example, with 6-9 months long hibernation seasons when body temperature alternates between levels near 0 C during torpor and 37 C during arousal episodes. Heat production during hibernation is provided, in part, by non-shivering thermogenesis that occurs in large deposits of brown adipose tissue (BAT). more...

Organism:

Mus musculus; Urocitellus parryii

Type:

Expression profiling by array

4 related Platforms

44 Samples

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(Submitter supplied) cDNA spot array on nylon membrane http://www.wistar.org/research_facilities/facilities/genomics/review.html

Organism:

Urocitellus parryii

2 Series

43 Samples

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(Submitter supplied) This array (2A) contains the second 707 genes designed from the mixed sequences of three close-related ground squirrel species: golden-mantled ground squirrel; thirteen-lined ground squirrel; arctic ground squirrel. Two 50bps probes were designed for each gene. Protocol: http://www.illumina.com/technology/platform/tech_plat_arraymfg.ilmn

Organism:

Urocitellus parryii; Ictidomys tridecemlineatus; Callospermophilus lateralis

1 Series

144 Samples

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(Submitter supplied) This array (1A) contains the first 707 genes designed from the mixed sequences of three close-related ground squirrel species: golden-mantled ground squirrel; thirteen-lined ground squirrel; arctic ground squirrel. Two 50bps probes were designed for each gene. Protocol: http://www.illumina.com/technology/platform/tech_plat_arraymfg.ilmn

Organism:

Urocitellus parryii; Ictidomys tridecemlineatus; Callospermophilus lateralis

1 Series

144 Samples

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