txid79327[Organism] - GEO DataSets

Search results

Items: 1 to 20 of 2862

<< First< Prev

Page of 144

Select item 2002555951.

Fibrillarin homologs are required for divergent cell lineage development by translational regulation in planarian homeostasis and regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schmidtea mediterranea

Type:: Other

Platform:: GPL29967
36 Samples

Download data: BEDGRAPH

Series

Accession:: GSE255595

ID:: 200255595

Select item 2002555942.

Fibrillarin homologs are required for divergent cell lineage development by translational regulation in planarian homeostasis and regeneration [Ribo-seq]

(Submitter supplied) Translational regulation in adult regenerative tissue remains unclear. Planarians, renowned for remarkable cell turnover and tissue regeneration capabilities, are regenerative flatworms that provide an ideal model to address the gap in knowledge between translational control and cell turnover during adult tissue homeostasis and regeneration. Fibrillarin (FBL) is an RNA 2-O’-methyltransferase crucial for rRNA processing, playing a pivotal role in translational regulation. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL29967
24 Samples

Download data: TXT

Series

Accession:: GSE255594

ID:: 200255594

Select item 2002555903.

Fibrillarin homologs are required for divergent cell lineage development by translational regulation in planarian homeostasis and regeneration [RiboMeth-Seq]

Organism:: Schmidtea mediterranea

Type:: Other

Platform:: GPL29967
12 Samples

Download data: BEDGRAPH

Series

Accession:: GSE255590

ID:: 200255590

Select item 2002666614.

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [RNAi scRNA-seq]

(Submitter supplied) To further identity the relationship between neoblast pluripotency and mitochondrial dynamics in cell lineage commitment,single-cell RNA sequencing was used to further analyze the compositions of mito low cells. To further identify the relationship between all different tissues cells and mito chondrial dynamics, snRNA-seq was used to further analyisis.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20150
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE266661

ID:: 200266661

Select item 2002440705.

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20150 GPL29967
71 Samples

Download data: MTX, TAR, TSV

Series

Accession:: GSE244070

ID:: 200244070

Select item 2002440696.

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [scRNA-seq]

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20150
2 Samples

Download data: TAR

Series

Accession:: GSE244069

ID:: 200244069

Select item 2002440687.

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [bulk RNA-seq]

(Submitter supplied) To investigate the mechanism of mitochondrial morphology in neoblast pluripotenc and whole body regeneration,the Bulk RNA-seq and single cell RNA-seq data were needed.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
60 Samples

Download data: CSV

Series

Accession:: GSE244068

ID:: 200244068

Select item 2002617228.

Identification of EV-responsive transcripts in the planarian Schmidtea mediterranea

(Submitter supplied) The roles of extracellular vesicles in animal models of regeneration are poorly characterized. The goal of this study was to identify differentially expressed transcripts in planarian flatworms after injection of buffer only or extracellular vesicles compared to uninjected animals.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34306
24 Samples

Download data: TXT

Series

Accession:: GSE261722

ID:: 200261722

Select item 2002678659.

A niche-derived non-ribosomal peptide triggers planarian sexual development.

(Submitter supplied) Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche cells expressing a non-ribosomal peptide synthetase (nrps). Inhibiting nrps led to loss of female reproductive organs and testis hyperplasia. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE267865

ID:: 200267865

PubMed Full text in PMC Similar studies

Select item 20025603210.

Multiplex single cell analysis of serotonergic neuron function in planarians reveals widespread effects in diverse cell types

(Submitter supplied) We used scRNA-seq to examine serotonergic function in asexual planarians. We profiled 47,292 single cell transcriptomes of planarian of 3 different RNAi categories: gfp(RNAi), lhx1/5-1(RNAi) and pitx(RNAi). We detected changes in cell type frequency and gene expression patterns in planarian of different knock-down conditions, capturing regulatory programs of distinct cell types in response to loss of serotonergic function.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE256032

ID:: 200256032

Select item 20024668111.

Allometry of cell types in planarians by single cell transcriptomics

(Submitter supplied) We used scRNA-seq to examine cell type allometry in asexual planarians. We profiled 28,738 single cell transcriptomes of planarian of 3 different sizes categories: small (S), medium (M) and large (L). We detected changes in cell type frequency and gene expression patterns in planarian of different sizes, capturing regulatory programs of distinct cell types in response to allometric scaling.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE246681

ID:: 200246681

Select item 20024151612.

aristaless-like homeobox-3 is wound induced in muscle and stem cells and is required for planarian head regeneration

(Submitter supplied) To investigate the role of alx-3 in activating wound-induced transciptional programs during anterior regneneraiton, control(RNAi) and alx-3(RNAi) planarians were amputated below the pharynx and were allowed to regenerate for 0.5 hours post-amputation (HPA), 6HPA, 24HPA, 48HPA and 72HPA. Intact animals were are also included.Tissue from tail fragments and intact animals was collected at each time point for RNA extraction and cDNA synthesis. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
36 Samples

Download data: XLSX

Series

Accession:: GSE241516

ID:: 200241516

PubMed Full text in PMC Similar studies

Select item 20021213613.

High throughput expression-based phenotyping and RNAi screening reveals novel regulators of planarian stem cells

(Submitter supplied) The complexity of cell types and states revealed by scRNAseq cell atlases presents a challenge for the systematic analysis of fate determinants using traditional screening methodologies. Differentiation in the planarian Schmidtea mediterranea exemplifies this problem, as these animals continuously produce over 100 differentiated cell types for homeostasis and regeneration using adult pluripotent stem cells termed neoblasts. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21689
75 Samples

Download data: XLSX

Series

Accession:: GSE212136

ID:: 200212136

Select item 20023154814.

Depletion of 16S ribosomal RNA improves single-cell RNA-seq of planarians by DASH

(Submitter supplied) Single-cell transcriptomics (scRNA-seq) has revolutionized our understanding of cell types and states in various contexts, such as development and disease. Most methodology relies on poly(A) enrichment to selectively capture protein-coding polyadenylated transcripts, intending to exclude ribosomal transcripts that constitute >80% of the transcriptome. However, it is common for ribosomal transcripts to sneak into the library, which can add significant background by flooding libraries with irrelevant sequences. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33372
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE231548

ID:: 200231548

PubMed Full text in PMC Similar studies

Select item 20019252415.

Genome-wide analysis of planarian piRNAs

(Submitter supplied) Sample dataset for the described bioinformatic pipeline (piRNAnalyzer) comprising epidermal piRNA libraries of Schmidtea mediterranea

Organism:: Schmidtea mediterranea

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21689
3 Samples

Download data: BW

Series

Accession:: GSE192524

ID:: 200192524

PubMed Similar studies

Select item 20020292816.

m6A Modification Regulates Planarian Regeneration [scRNA-seq]

(Submitter supplied) Regeneration is the regrowth of damaged tissues or organs, a vital mechanism in response to damages from primitive organisms to higher mammals. Planarian possesses active whole-body regenerative capability owning to its vast reservoir of adult stem cells, neoblasts, providing an ideal model to delineate the underlying mechanisms for regeneration. RNA N6-methyladenosine (m6A) modification participates in many biological processes, including stem cell self-renewal and differentiation, in particular the regeneration of hematopoietic stem cells and axons. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
10 Samples

Download data: TXT

Series

Accession:: GSE202928

ID:: 200202928

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017124917.

m6A Modification Regulates Planarian Regeneration [MeRIP-seq]

(Submitter supplied) The fundamental of regeneration process of invertebrates involves the renewal, differentiation and reprogramming of stem cell in an orchestrated manner. It has been known that N6-methyladenosine (m6A) regulates stem cell renewal and differentiation. It is still unclear if m6A is crucial for the regeneration at whole-organism level. Here, we demonstrate that wtap knockdown mediated m6A depletion impairs planarian regeneration upon amputation. more...

Organism:: Schmidtea mediterranea

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL29967
30 Samples

Download data: TXT

Series

Accession:: GSE171249

ID:: 200171249

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017124718.

m6A Modification Regulates Planarian Regeneration [RNA-seq]

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
30 Samples

Download data: TXT

Series

Accession:: GSE171247

ID:: 200171247

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017125319.

m6A Modification Promotes Planarian Regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schmidtea mediterranea

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL29967
70 Samples

Download data

Series

Accession:: GSE171253

ID:: 200171253

PubMed Full text in PMC Similar studies

Select item 20022715520.

Identification of dysregulated transcripts in egr-2(RNAi) planarians

(Submitter supplied) egr-2 is an injury-responsive gene that is upregulated in the anterior of planarian tail fragments and required for intestinal remodeling. The goal of this study was to identify differentially expressed transcripts in the anterior region of egr-2(RNAi) tail fragments relative to egfp(RNAi) control fragments.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30113
24 Samples

Download data: TXT

Series

Accession:: GSE227155

ID:: 200227155

<< First< Prev

Page of 144

Next >Last >>

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Search results

Items: 1 to 20 of 2862

Send to:

Supplemental Content

Find related data

Search details

Important Links

Recent activity