GEO DataSets

(Submitter supplied) Background: In immunodeficient mice, the growth and reproduction of schistosome were significantly retarded, and their virulence on the host was also weakened. Some studies have suggested that host factors including endocrine and immune signals can modulate the parasite’s development and maturation. However, it is still not clear for the molecular mechanisms underlying the growth and maturation regulation of schistosome. more...

Organism:

Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL25265

4 Samples

Download data: FA, TXT, XLS

(Submitter supplied) To date, 115 miRNAs genes (precursors) have been registered in miRBase for Schistosoma mansoni, and 56 for Schistosoma japonicum (225 and 79 mature miRNA, respectively). miRNAs have not been systematically described in Schistosoma haematobium. Our aim in this study was to systematically characterize and quantify miRNA in Schistosoma by species, developmental stage and sex and to test the usefulness of this characterization in biomarker discovery for infection. more...

Organism:

Schistosoma japonicum; Schistosoma mansoni; Schistosoma haematobium

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL25265 GPL25263 GPL21570

60 Samples

Download data: TXT

(Submitter supplied) Background: In immunodeficient mice, the growth and egg laying of schistosome were significantly retarded or inhibited, and their virulence on the host was also weakened. Some studies have suggested that host factors including endocrine and immune signals can modulate the parasite’s development and maturation. However, it is still not clear for the molecular mechanisms underlying the growth and maturation regulation of schistosome. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25265

4 Samples

Download data: FASTA, GTF, XLS

(Submitter supplied) To investigate microRNAs (miRNAs) involving in the regulation of the schistosome development and survival, we compared miRNA expression profiles of adult Schistosoma japonicum derived from yellow cattle and water buffalo using high-throughput sequencing with Illumina Hiseq Xten.

Organism:

Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL25984

8 Samples

Download data: TXT

(Submitter supplied) Purpose: To obtain the differentially expressed genes based on post-RNAi transcriptional profiling analysis of females and males, which provide a more comprehensive overview about the effects of Sj-pp1c knockdown on schistosoma developmental and reproduction biology at the molecular level. Methods: Schistosoma japonicum females and males were collected from 21 days post infection worm pairs that untreated (Blank,BLA_FE/M) or treated with combined Sj-pp1c dsRNAs (Sj-pp1c KD,PP1_FE/M) cultured for 7 d in vitro. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20772

12 Samples

Download data: TXT

(Submitter supplied) The microarray analysis of gene expression difference between cattle,buffalo and goat,provide us a profiling as a new platform to discover the difference between their compatibility

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL10987

9 Samples

Download data: TXT

(Submitter supplied) In the complex lifecycle of schistosomes, four developmental stages are closely associated with their definitive hosts: cercaria (infective stage), schistosomula and adult worm (parasitic stages), egg (pathogenic- and pathophoresis-stage). We have examined the gene expression profiles of Schistosoma japonicum in the four developmental stages. Genes with different expression patterns were identified and the information obtained will help indentify new anti-schistosomal intervention targets in the future.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL18617

23 Samples

Download data: PAIR

(Submitter supplied) We report on the small RNA profiles of Schistosoma japonicum (S. japonicum) miRNAs using small RNA deep sequencing in the key stages of male-female pairing, gametogenesis, and egg production.

Organism:

Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL20772

8 Samples

Download data: TXT

(Submitter supplied) Alternative splicing is a molecular process that contributes greatly to the diversification of proteome and to gene functions. Understanding the mechanisms of stage-specific alternative splicing can provide a better understanding of the development of eukaryotes and the functions of different genes. Schistosoma japonicum is an infectious blood-dwelling trematode with a complex lifecycle that causes the tropical disease schistosomiasis. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20772

1 Sample

Download data: FASTA, XLS

(Submitter supplied) Although numerous researches on schistosomiasis japonica have been performed using laboratory animal models, the comparison of gene expression profiles of S. japonicum from the different laboratory animals and natural hosts is still a gap. We systematically compared the gene expression profiles of schistosomes from different laboratory animals and water buffaloes. The findings of this study provide the basis for schistosomiasis research in different mammalian hosts at transcriptional level and valuable resource for the screening of anti-schistosomal intervention targets.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL18617

24 Samples

Download data: PAIR

(Submitter supplied) In this study, we isolated and identified the small RNAs associated with the S. japonicum Argonaute protein, SjAgo1, by HITS-CLIP combined with bioinformatic analysis. These data reveal a genome-wide miRNA-mRNA interaction map in S. japonicum in vivo, which will help us understand the complex gene regulation network in this pathogen and thereby facilitate to develop novel approaches against Schistosomiasis.

Organism:

Schistosoma japonicum

Type:

Other

Platform:

GPL11650

1 Sample

Download data: FA, TXT

(Submitter supplied) Background: Schistosoma japonicum is a pathogen of the phylum Platyhelminths that causes zoonotic schistosomiasis endemic in China and Southeast Asian countries. Control of the disease has been hampered by the lack of efficient measures. The development of tools for diagnosis of acute and chronic infection, and novel antiparasite reagents all relies on the understanding of the biological mechanism of the parasite. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18816

2 Samples

Download data: XLS

(Submitter supplied) We have used a Schistosoma japonicum infected murine model with in vivo sub-lethal dosages of praziquantel against adult parasites. Differential gene expression of parasites was followed between 30 minutes and 24 hours post- drug administration, using a whole transcriptome microarray platform. Differential gene expression was considered separately between parasite gender.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL9759

20 Samples

Download data: TXT

(Submitter supplied) Chinese and Philippine strains of the blood fluke Schistosoma japonicum present clear and distinctive phenotypes in areas of fecundity, pathology, drug sensitivity and immunology. Despite these differences large scale sequencing efforts have focused solely on Chinese mainland strain of the parasite. We have undertaken a comparative genomic hybridisation (CGH) approach to highlight some of the structural differences in the genome of two of the major geographical isolates of S. more...

Organism:

Schistosoma japonicum

Type:

Genome variation profiling by array

Platform:

GPL9759

8 Samples

Download data: TXT

(Submitter supplied) Suppression subtractive hybridization(SSH) libraries of Schistosoma japanicum female and male worms were constructed by using Clontech PCR-selectTM cDNA subtraction kit. S.japonicum cDNA microarrays were fabricated using female and male cDNA clones originating from SSH libraries. female-associated and Male-associated differentially expressed gene clones were obtained, Analysis of gender-associated differentially expressed genes helps to determine which genes are important to sexual maturation of schistosome and better understand schistosome biology and host-parasite relationship, facilitate the discovery of novel gene products that could represent targets for the development of new drugs and vaccines to control chitosomiasis. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL3075

4 Samples

Download data: GPR, TIFF

(Submitter supplied) Schistosoma japonicum is one of the remarkable platyhelminths that are endemic in the South Asian countries. The parasite is dioecious and can parasitize inside host blood stream for many years. Rapid reproduction by producing large number of eggs and count-react or active manipulating host anti-parasite responses are the strategies that benefit the long term parasitization of the parasite. Currently, Praziquantel is the only commercial drug that is effective against the worms but not the eggs of parasite in the host and no vaccine available to prevent human or animal schistosomiasis. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11650

2 Samples

Download data

(Submitter supplied) More than 40 species of mammal have been reported to be infected naturally with Schistosoma japonicum (Chinese mainland strain) in China. The reed vole, Microtus fortis, is the only known mammalian host in which the schistosomes are unable to mature and cause significant pathogenic changes. Gene expression profiling of the 10 day old schistosomula was performed.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL9759

4 Samples

Download data: TXT

(Submitter supplied) We have examined the gene expression profile of the transformation of the blood fluke Schistosoma mansoni from the cercarial to schistosomula stages. Specifically cercariae were mechanically transformed and then cultured for 3 hours or 5 days, and then total RNA was isolated and microarray analysis performed. A second experiment compares the effect that the presence of red blood cell in the culturing conditions has over the 3 hour and 5 day periods have on the parasite.

Organism:

Schistosoma mansoni; Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL7160

10 Samples

Download data

(Submitter supplied) Analysis of differentially expressed gene of different parasite stage helps to determine which genes are likely to be the key players in transition through a developmental stage, thus help to further understand schistosome biology and host-parasite relationship, facilitate the discovery of novel gene products than could represent targets for the development of new drugs and vaccines to control schitosomiasis.Samples were analyzed at cercariae, egg and adult worm stage. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL1944

8 Samples

Download data: GPR, TIFF

(Submitter supplied) Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide. Determining the molecular mechanisms regulating the development of granulomas and fibrosis will be essential for understanding how schistosome antigens interact with the host environment. We report here the first whole genome microarray analysis of the murine liver during the progression of Schistosoma japonicum egg-induced granuloma formation and hepatic fibrosis. more...

Organism:

Schistosoma japonicum; Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

10 Samples

Download data: TXT