GEO DataSets

(Submitter supplied) The interrelationships between our diets and the structure and operations of our gut microbial communities are poorly understood. A model microbial community of ten sequenced human gut bacteria was introduced into gnotobiotic mice and changes in the abundance of each species were measured in response to randomized perturbations of four defined ingredients in the host diet. From the responses, we developed a statistical model that predicted over 50% of the variation in species abundance in response to the diet perturbations and were able to identify which factors in the diet best explained the changes seen for each community member. more...

Organism:

Marvinbryantia formatexigens DSM 14469; Collinsella aerofaciens ATCC 25986; Bacteria; [Clostridium] symbiosum; Bacteroides thetaiotaomicron VPI-5482; Bacteroides ovatus ATCC 8483; Bacteroides caccae ATCC 43185; Agathobacter rectalis ATCC 33656; Desulfovibrio piger GOR1; Blautia hydrogenotrophica DSM 10507; Escherichia coli str. K-12 substr. MG1655

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL11535

490 Samples

Download data: TXT

(Submitter supplied) Fermenting microbial communities generate hydrogen: its removal through production of acetate, methane, or hydrogen sulfide modulates the efficiency of energy extraction from available nutrients in many ecosystems. We noted that pathway components for acetogenesis are more abundantly and consistently represented in the gut microbiomes of monozygotic twins and their mothers than components for methanogenesis or sulfate reduction, and subsequently analyzed the metabolic potential of two sequenced human gut acetogens, Blautia hydrogenotrophica and Marvinbryantia formatexigens in vitro and in the intestines of gnotobiotic mice harboring a prominent saccharolytic bacterium. more...

Organism:

Marvinbryantia formatexigens DSM 14469; Escherichia coli str. K-12 substr. MG1655; Bacteroides thetaiotaomicron VPI-5482; Blautia hydrogenotrophica DSM 10507

Type:

Expression profiling by high throughput sequencing

6 related Platforms

119 Samples

Download data: TXT