txid10090[orgn] AND "strain mdx"[All Fields] - GEO DataSets

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Select item 2001996591.

Spatial transcriptomics (Visium, 10x Genomics) data of Duchenne mouse models

(Submitter supplied) Quadricep sections of 10µm thick were placed on Visium spatial transcriptomics slide to obtain spatial datasets for these skeletal muscle sections

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: CSV, H5, JPG, JSON, MTX, PNG, TSV, TXT

Series

Accession:: GSE199659

ID:: 200199659

PubMed Full text in PMC Similar studies

Select item 2001975532.

Mineralocorticoid Receptor Antagonists and Glucocorticoids Differentially Affect Skeletal Muscle Inflammation and Pathology in Muscular Dystrophy

(Submitter supplied) We report the RNA Sequencing of myleoid cells isolated from 4.5-week-old mdx mice that were administered spironolactone, prednisolone, or vehicle for 7 days. We find that both spironolactone and prednisolone downregulated expression of genes involved in inflammation and fibrosis, while prednisolone further perturbed cell cycle genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28457
9 Samples

Download data: CSV, TXT

Series

Accession:: GSE197553

ID:: 200197553

PubMed Full text in PMC Similar studies

Select item 2001898253.

Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
36 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE189825

ID:: 200189825

PubMed Full text in PMC Similar studies

Select item 2001898234.

Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence [ChIP-seq]

(Submitter supplied) Pharmacological treatment of Duchenne Muscular Dystrophy (DMD) with histone deacetylase inhibitors (HDACi) is currently being tested in clinical trials. Pre-clinical studies performed in mdx mice - the mouse model of DMD - have shown that HDACi promote compensatory muscle regeneration, while inhibiting fibro-adipogenic degeneration, by targeting fibro-adipogenic progenitors (FAPs); however, these beneficial effects are restricted to early stages of disease progression. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE189823

ID:: 200189823

PubMed Full text in PMC Similar studies

Select item 2001586665.

Differential expression of Triggering Receptor Expressed on Myeloid Cells (Trem)-2 in tissue eosinophils

(Submitter supplied) No longer regarded as simply end-stage cytotoxic effectors, eosinophils are now recognized as complex cells with unique phenotypes that develop in response to the local microenvironment. In our previous study, we documented eosinophil infiltration in association with characteristic muscle damage in the dystrophin-deficient (mdx) mouse model of Duchenne muscular dystrophy. In this earlier study, we found that eosinophils did not promote formation of muscle lesions, as these persisted in eosinophil-deficient mdx.PHIL mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
9 Samples

Download data: TXT

Series

Accession:: GSE158666

ID:: 200158666

SRA Run Selector

Select item 2000809626.

Gene expression for treatment of bioceramic water

(Submitter supplied) Increased oxidative stress induces impairment of the antioxidant defense systems and defects in regeneration of injured tissues. We aim to evaluate the effects of antioxidant bioactive ceramic water (JJ101) on tissue repairing and anti-aging. In vitro, myogenic and antioxidant factors were determined in satellite cells cultured in JJ101 media. Satellite cells grown in JJ101 medium displayed increased expression of Notch1, Pax7, AMP-activating protein kinase-alpha (AMPK-alpha) and anti-oxidant enzymes and significant protection against hydrogen peroxide-induced cell death. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
6 Samples

Download data: TXT

Series

Accession:: GSE80962

ID:: 200080962

Analyze with GEO2R

Select item 2000214987.

Dystrophic single myofibers vs. control single myofibers

(Submitter supplied) MicroRNA-expression profile of dystrophic single fibers compared to wild type single fibers isolated from different muscles of mdx and C57BL mice.

Organism:: synthetic construct; Homo sapiens; Mus musculus; Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL10336
18 Samples

Download data: TXT

Series

Accession:: GSE21498

ID:: 200021498

Analyze with GEO2R

Select item 2000527668.

The effects of muscular dystrophy, exercise and sActRIIB-Fc on molecular signature of skeletal muscle in mice

(Submitter supplied) To study the combined effect of myostatin/activin inhibition and exercise on muscle mass and pathophysiology, young mdx mice, a model for Duchenne Muscular Dystrophy, were injected with soluble activin receptor-Fc (sActRIIB-Fc) or placebo (PBS) 1x/week for a 7-week period, in combination with or without voluntary running. C57Bl/10ScSnJ mice injected with PBS acted as wildtype controls. Microarray expression analysis from skeletal muscle was performed using m. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
24 Samples

Download data: TXT

Series

Accession:: GSE52766

ID:: 200052766

Select item 2000252589.

Cells isolated from diaphragm of mdx mouse: satellite cells vs. PDGFRa+ cells

(Submitter supplied) Transcriptional profiling of mouse skeletal muscle-derived cells comparing satellite cells with PDGFRa+ cells. Satellite cells and PDGFRa+ cells were directly isolated from diaphragm of dystrophic mdx mouse by FACS.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5642
1 Sample

Download data: GPR

Series

Accession:: GSE25258

ID:: 200025258

Select item 20000718710.

Microarray analysis of mdx mice expressing high levels of utrophin: therapeutic implications for DMD

(Submitter supplied) Duchenne Muscular Dystrophy (DMD) is a fatal muscle wasting disorder caused by dystrophin deficiency. Previous work suggested that increased expression of the dystrophin-related protein utrophin in the mdx mouse model of DMD can prevent dystrophic pathophysiology. Physiological tests showed that the transgenic mouse muscle functioned in a way similar to normal muscle. More recently, it has become possible to analyse disease pathways using microarrays, a sensitive method to evaluate the efficacy of a therapeutic approach. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3398
Platform:: GPL339
17 Samples

Download data: CEL

Series

Accession:: GSE7187

ID:: 200007187

Select item 339811.

Utrophin overexpression effect on dystrophin-deficient mdx skeletal muscles

Analysis of skeletal muscles from dystrophin-deficient mdx trangenics engineered to overexpress utrophin, a dystrophin-related protein. Dystrophin mutations result in Duchenne muscular dystrophy. mdx trangenics overexpressing utrophin display improved muscle function.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 strain sets

Platform:: GPL339
Series:: GSE7187
17 Samples

Download data: CEL

DataSet

Accession:: GDS3398

ID:: 3398

Select item 20000147212.

Extraocular and hindlimb muscle, comparison of wild type and mdx mice, 56 days (Porter lab)

(Submitter supplied) Determination of gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56. 5 independent replicates/muscle group/strain. Keywords: parallel sample

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS703
Platform:: GPL32
20 Samples

Download data: CEL

Series

Accession:: GSE1472

ID:: 200001472

Select item 70313.

Dystrophin-deficient mdx extraocular and leg muscle

Analysis of extraocular (EOM) and hindlimb (gastrocnemius/soleus) muscle in mdx (dystrophin-deficient; Duchenne muscular dystrophy model) mice at postnatal day 56.5. Highly specific changes observed between dystrophic (leg) and spared (EOM) muscle.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 strain, 2 tissue sets

Platform:: GPL32
Series:: GSE1472
20 Samples

Download data: CEL

DataSet

Accession:: GDS703

ID:: 703

Select item 20000089714.

Molecular profiles of dystrophin-deficient and normal murine muscle

(Submitter supplied) Expression profiles of six skeletal muscle types in mdx, mdx5cv and wildtype mice. Keywords: other

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS641
Platform:: GPL81
36 Samples

Download data: CEL, EXP, RPT

Series

Accession:: GSE897

ID:: 200000897

Select item 64115.

Dystrophin-deficient mdx, mdx5cv and wild type skeletal muscle profiles

Analysis of diaphragm, extensor digitorum longus, gastroc, soleus, quadricep, and tibialis anterior muscle in 8 week old male dystrophin-deficient mdx, mdx5cv, and C57BL10 wild type provides insight into pathogenesis of muscular dystrophy.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 strain, 6 tissue sets

Platform:: GPL81
Series:: GSE897
36 Samples

Download data: CEL, EXP, RPT

DataSet

Accession:: GDS641

ID:: 641

Select item 20000102616.

Diaphram, comparison of wild type and mdx mice, 7 to 112 Days (Porter lab)

(Submitter supplied) Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004. Keywords = microarray Keywords = muscle Keywords: time-course

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS638
Platform:: GPL81
36 Samples

Download data: CEL

Series

Accession:: GSE1026

ID:: 200001026

Select item 20000102517.

Hindlimb muscle, comparison of wild type and mdx mice, 7 to 112 Day (Porter lab)

(Submitter supplied) Determination of gene expression changes in hindlimb muscle (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112. Keywords: time-course

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS639
Platform:: GPL81
36 Samples

Download data: CEL

Series

Accession:: GSE1025

ID:: 200001025

Select item 63918.

Dystrophin-deficient mdx hindlimb muscle development time course

Temporal analysis of hindlimb gastrocnemius/soleus muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 6 age, 2 strain sets

Platform:: GPL81
Series:: GSE1025
36 Samples

Download data: CEL

DataSet

Accession:: GDS639

ID:: 639

Select item 63819.

Dystrophin-deficient mdx diaphram muscle development time course

Temporal analysis of diaphram muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.