txid10090[orgn] AND "strain M musculus"[All Fields] - GEO DataSets

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Select item 2000170641.

Genome-wide identification of Polycomb-associated RNAs by RIP-seq

(Submitter supplied) Large-scale analyses have revealed that 60-90% of the mammalian genome is transcriptionally active. Because <2% of sequences have protein-coding potential, why so much cellular energy is expended on RNA synthesis is a major question in the post-genomic era. The hypothesis that RNA may serve as recruiting platforms for chromatin modifiers has gained ground with discoveries linking long ncRNAs, such as RepA, Xist, and Tsix, to locus-specific targeting of Polycomb proteins to the X-chromosome. more...