txid10090[orgn] AND "strain FBV/N"[All Fields] - GEO DataSets

(Submitter supplied) The tumor suppressor LATS1, whose expression is often downregulated in human breast cancer, helps maintain luminal breast cancer cell identity by keeping basal-specific genes in a closed chromatin state, preventing their spurious activation. This is achieved via interaction of LATS1 with the NCOR1 nuclear corepressor and recruitment of HDAC1,driving histone H3K27 deacetylation near NCOR1-repressed “basal” genes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: XLSX

Series

Accession:: GSE195715

ID:: 200195715

PubMed Full text in PMC Similar studies

Select item 2001957143.

Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis [ATAC-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: BED

Series

Accession:: GSE195714

ID:: 200195714

PubMed Full text in PMC Similar studies

Select item 2001186194.

Foxp1 is indispensable for ductal morphogenesis and controls the exit of mammary stem cells from quiescence [RNA-seq and ChIP-seq]

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112
16 Samples

Download data: TXT

Series

Accession:: GSE118619

ID:: 200118619

PubMed Similar studies

Select item 2001186185.

ChIP-seq profiling of Foxp1 binding in basal and luminal mouse mammary cells

(Submitter supplied) Long-lived quiescent mammary stem cells (MaSCs) are presumed to coordinate the dramatic expansion of ductal epithelium that occurs through the different phases of postnatal development, but little is known about the molecular regulators that underpin the activation of MaSCs. Here we show that ablation of the transcription factor Foxp1 in the mammary gland profoundly impairs ductal morphogenesis, resulting in a rudimentary tree throughout adult life. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE118618

ID:: 200118618

PubMed Similar studies SRA Run Selector

Select item 2001004776.

Transgenic expression of miR-32 in mouse ventral and dorsolateral prostate

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
4 Samples

Download data: TXT

Series

Accession:: GSE100477

ID:: 200100477

Select item 2001004757.

Transgenic expression of miR-32 in mouse ventral prostate

(Submitter supplied) Transcriptional profiling of ventral prostate of mice with prostate-specific transgenic expression of miR-32 compared with wild type mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
2 Samples

Download data: TXT

Series

Accession:: GSE100475

ID:: 200100475

Select item 2000587298.

The ETS transcription factor Elf5 drives lung metastasis in luminal breast cancer via recruitment of Gr-1+CD11b+ myeloid derived suppressor cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
18 Samples

Download data: CEL

Series

Accession:: GSE58729

ID:: 200058729

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000587289.

The ETS transcription factor Elf5 drives lung metastasis in luminal breast cancer via recruitment of Gr-1+CD11b+ myeloid derived suppressor cells [chronic]

(Submitter supplied) Elf5 expression in mammary progenitor cells regulates a cell fate decision that establishes the alveolar cell lineage. In luminal breast cancer cells, increased Elf5 expression suppressed estrogen receptor and FoxA1 expression and was implicated in the acquisition of resistance to the cytostatic effects of antiestrogen therapy. We show that in the PyMT model of luminal breast cancer, increased Elf5 expression drives lung metastasis by recruiting myeloid-‐derived suppressor cells, and that this activity overcomes the epithelializing influence of Elf5. more...