txid10090[orgn] AND "strain F1 129S1/CastEiJ x 129S4"[All Fields] - GEO DataSets

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Select item 2000676671.

Probing Xist RNA structure in cells using Targeted Structure-Seq

(Submitter supplied) The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells. Models for how Xist and other lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the context of a cell. Probing accessible RNA bases can provide data to build models of RNA conformation that provide insight into RNA function, molecular evolution, and modularity. more...