GEO DataSets

(Submitter supplied) The goal of this experiment is to profile longitudinal transcriptome changes during the development of murine arthritis in CIA mouse model. Male DBA1 mice (age between 10 to 12 weeks) were used in this study. CIA was induced by two immunizations with Type II collagen in Complete Freund’s adjuvant (CFA) at day 0, and with Type II collagen in Incomplete Freund’s adjuvant (IFA) at day 21. Bulk RNA-seq were done on right hind paws from control (non-immunized DBA1 mice) and CIA mice at different disease stages (up to 10 weeks after 1st immunization).

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21626

171 Samples

Download data: CSV

(Submitter supplied) DBA1 mice with collagen-induced arthritis were injected intra-articularly with miR-17-5p mimic lipoplex. At the peak of inflammation (day 7), ankles were processed for bulk RNAseq using Illumina NextSeq 500.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

7 Samples

Download data: TXT

(Submitter supplied) Different mosue strains showed different sensitivity to anti-GBM antibody induced glomerulai nephritis. By analyze the renal gene expressin profiles in different mouse stains after challenging with anti-GBM antibody, we will be able to identify the genes and pathway underlining the anti-GBM nephritis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL18108 GPL6105

18 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease states, including inflammatory autoimmune diseases. By using high-throughput microRNA profiling analysis, we identified a series of miRNAs dysregulated in local inflammatory lesions of human patients with autoimmune diseases, as well as their relevant mouse models such as CIA.

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL15466

4 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease states, including inflammatory autoimmune diseases. By using high-throughput microRNA profiling analysis, we identified a series of miRNAs dysregulated in local inflammatory lesions of human patients with autoimmune diseases such as SLE. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by RT-PCR; Expression profiling by array

4 related Platforms

34 Samples

Download data: CEL