txid10090[orgn] AND "strain C3B6F4"[All Fields] - GEO DataSets

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Select item 2000924861.

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

(Submitter supplied) Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during ageing and extends lifespan in diverse species including rodents and rhesus monkeys. However the mechanisms by which DR interacts with the ageing process to improve health at old age are poorly understood. DNA methylation could play an important role in mediating the effects of DR, because it is sensitive to the effects of nutrition and can affect gene expression memory over time. more...