GEO DataSets

(Submitter supplied) Tissue iron (Fe) overload is a frequent pathologic finding in multiple disease states including non-alcoholic fatty liver disease (NAFLD), neurodegenerative disorders, cardiomyopathy, diabetes, and some forms of cancer. The role of iron, as a cause or consequence of disease progression and observed phenotypic manifestations, remains controversial. In addition, the impact of genetic variation on iron overload related phenotypes is unclear, and the identification of genetic modifiers is incomplete. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

127 Samples

Download data: TXT

(Submitter supplied) Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise intervention in middle-aged men and a panel of 100 diverse strains of female mice. Candidate gene analyses in three brain regions, muscle, liver, heart, and adipose tissue of mice revealed genetic drivers of clinically relevant traits including volitional exercise volume, muscle metabolism, adiposity, and hepatic lipids. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21493 GPL24247

499 Samples

Download data: TXT

(Submitter supplied) Identify genes in the heart whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The TPM values of genes were used for genome wide association. These data are used to identify candidate genes at loci associated with cardiovascular traits.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

187 Samples

Download data: TXT

(Submitter supplied) This project will chart with high-resolution the genetic pathways that give rise to defined clinical phenotypes related to cocaine addiction. We will utilize the power of the hybrid mouse diversity panel (HMDP), combined with high quality behavioral phenotyping and massive-scale RNA sequencing, to trace the interconnections from DNA to RNA to clinical trait and provide layered information on the mechanisms of cocaine abuse. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

392 Samples

Download data: TXT

(Submitter supplied) Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl4)-induced liver fibrosis using the Hybrid Mouse Diversity Panel (HMDP), a panel of over 100 genetically distinct mouse strains optimized for genome wide association studies and systems genetics. Chronic liver injury was induced by CCl4 injections twice weekly for six weeks. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

198 Samples

Download data: H5, TXT

(Submitter supplied) Identify genes in the heart whose expressions under genetic regulation in the hybrid mouse diversity panel. The hybrid mouse diversity panel is comprised of classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Bennett et al Genome Research 2010. These data used to identify candidate genes at loci associated with atherosclerosis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

99 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

586 Samples

Download data: CEL

(Submitter supplied) Identify genes in the aorta whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. 104 of these strains were bred onto a C57BL/6J background carrying transgenes for both ApoE-Leiden and cholesteryl ester transfer protein (CETP). The RMA values of genes were used for genome wide association as described in Davis et al PLOS Genetics 2015. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

366 Samples

Download data: CEL

(Submitter supplied) Identify genes in the liver whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. 104 of these strains were bred onto a C57BL/6J background carrying transgenes for both ApoE-Leiden and cholesteryl ester transfer protein (CETP). The RMA values of genes were used for genome wide association as described in Davis et al PLOS Genetics 2015. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

220 Samples

Download data: CEL

(Submitter supplied) Heritable epigenetic factors can contribute to complex disease etiology. In this study we examine, on a global scale, the contribution of DNA methylation to complex traits that are precursors to heart disease, diabetes and osteoporosis. We profiled DNA methylation patterns in the liver using bisulfite sequencing in 90 mouse inbred strains, genome-wide expression levels, proteomics, metabolomics and sixty-eight clinical traits, and performed epigenome-wide association studies (EWAS). more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL13112

105 Samples

Download data: CGMAP

(Submitter supplied) Identify genes in the skeletal muscle whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The neqc-normalized values of genes were used for genome wide association. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

112 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6885 GPL8759

984 Samples

Download data: CEL

(Submitter supplied) Identify genes in the liver whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Parks et al Cell Metabolism 2015. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

433 Samples

Download data: CEL

(Submitter supplied) Identify genes in the gonadal adipose tissue whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Parks et al Cell Metabolism 2015. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

439 Samples

Download data: CEL

(Submitter supplied) Identify genes in the epididymal adipose tissue whose expression is under genetic regulation in the hybrid mouse diversity panel. The hybrid mouse diversity panel is comprised of classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Bennett et al Genome Research 2010. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

185 Samples

Download data: CEL

(Submitter supplied) Identify genes in the aorta whose expressions under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HDMP is comprised of classical inbred and recombinant inbred wild-type mice. The RMA values of genes were used for genome-wide association as described in Bennett et al. Genome Research 2010 (PMID 20054062). These data were used to identify candidate genes at loci associated with atherosclerosis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

188 Samples

Download data: CEL

(Submitter supplied) Identify genes involved in regulation of inflammatory responses and gene-environemnt interactions, in macrophages from a set of mouse inbred strains termed the HMDP. The HMDP is a genetically diverse mapping panel comprised of classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Bennett et al Genome Research 2010.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

511 Samples

Download data: CEL

(Submitter supplied) To uncover genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution. By integrating fear phenotypes, transcript profiling data from hippocampus and striatum and genotype information, two gene co-expression networks correlated with context-dependent immobility were identified. We prioritized the key markers and genes in these pathways using intramodular connectivity measures and structural equation modeling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3900

Platform:

GPL6885

198 Samples

Download data: TXT

Analysis of whole hippocampus and striatum from Hybrid Mouse Diversity Panel (HMDP) males exposed to a fear conditioning procedure. The HMDP panel 29 classical inbred strains and 71 recombinant inbred strains. Results provide insight into molecular mechanisms underlying fear phenotypes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 100 strain, 2 tissue sets

Platform:

GPL6885

Series:

GSE26500

198 Samples

Download data

(Submitter supplied) Significant advances have been made in the discovery of genes affecting bone mineral density (BMD); however, our understanding of its genetic basis remains incomplete. In the current study, genome-wide association (GWA) and co-expression network analysis was used in the recently described Hybrid Mouse Diversity Panel (HMDP) to identify and functionally characterize novel BMD genes. In the HMDP, a GWA of total body, spinal and femoral BMD revealed four significant associations (-log10P > 5.39) affecting at least one BMD trait on chromosomes (Chrs.) 7, 11, 12 and 17. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

149 Samples

Download data: TXT