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Items: 2

1.

SUM159_shEN1-2_NoDoxy_2L

Organism:
Homo sapiens
Source name:
SUM159PT
Platform:
GPL18573
Series:
GSE120957
Download data
Sample
Accession:
GSM3687056
ID:
303687056
2.

The EN1 transcription factor drives neural features and brain metastases in triple negative breats cancer (TNBC)

(Submitter supplied) To define transcriptional dependencies of TNBCs, we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that EN1 is overexpressed in TNBCs and its downregulation preferentially and significantly reduces cellular viability and tumorigenicity in TNBC cell lines. Based on RNA-seq and ChIPseq we found that EN1 regulates genes involved in angiogenesis, neurogenesis, and axon guidance in breast cancer cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
89 Samples
Download data: BED, CSV

Supplemental Content

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