GEO DataSet Links for SRA (Select 729340) - GEO DataSets

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Links from SRA

Items: 2

Select item 3013762651.

NBB2009-005

Organism:: Homo sapiens

Source name:: non-demented without AD-like pathology (healthy controls)

Platform:: GPL16288
Series:: GSE57152

Download data: TXT

Sample

Accession:: GSM1376265

ID:: 301376265

SRA Run Selector

Select item 2000571522.

Alternative poly(A) in Alzheimer's disase

(Submitter supplied) Alternative polyadenylation (APA) contributes to post-transcriptional regulation, but its role in Alzheimer’s disease (AD) is largely unknown. Using high-resolution SQUARE multiple 3’ primer-based sequencing, we discovered massive APA differences in temporal gyrus tissues from demented AD patients compared to either healthy controls or non-demented donors with AD neuropathology (NDWP). Advanced statistics, microfluidics RT-PCR and protein measurements validated known and novel APA-modified 3’-intact transcripts. more...