(Submitter supplied) N6-methyladenosine (m6A) is a common modification of mRNA, with potential roles in fine-tuning the RNA life cycle, but little is known about the pathways regulating this process and its physiological role. Here, we used mass-spectrometry to identify a dense network of proteins physically interacting with METTL3, a core component of the methyltransferase complex, and show that two of them, WTAP and KIAA1429, are required for methylation.
more...- Organism:
- Homo sapiens
- Type:
- Other
- Platforms:
- GPL15520 GPL16791
- 50 Samples
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