GEO DataSet Links for SRA (Select 32589147) - GEO DataSets

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Items: 2

Select item 3082133471.

813DNA

Organism:: Mus musculus

Source name:: Mouse midbrain

Platform:: GPL24247
Series:: GSE264165

Download data: COV

Sample

Accession:: GSM8213347

ID:: 308213347

SRA Run Selector

Select item 2002641652.

Developmental origins of Parkinson’s disease risk: developmental exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain

(Submitter supplied) Epidemiological studies show that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson’s disease (PD). Animal studies support a link between developmental dieldrin exposure and increased neuronal susceptibility in the α-synuclein preformed fibril (α-syn PFF) and MPTP models in adult male C57BL/6 mice. In a previous study, we showed that developmental dieldrin exposure was associated with sex-specific changes in DNA modifications within genes related to dopaminergic neuron development and maintenance at 12 weeks of age. more...