GEO DataSet Links for SRA (Select 32484907) - GEO DataSets

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Items: 2

Select item 3081904031.

MET32_Mutant_MNase

Organism:: Saccharomyces cerevisiae

Source name:: Yeast cells

Platform:: GPL19756
Series:: GSE263367

Download data: RDS

Sample

Accession:: GSM8190403

ID:: 308190403

SRA Run Selector

Select item 2002633672.

Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal mechanisms of chromatin-mediated transcriptional regulation

(Submitter supplied) Epigenetic mechanisms contribute to gene regulation by altering the accessibility of the chromatin, resulting in transcription factor (TF) and nucleosome occupancy changes throughout the genome. A major challenge is defining and dissecting this complex chromatin-mediated code to model transcriptional regulation and predict gene expression. We address this by employing a factor-agnostic, reverse-genetics approach to capture TF and nucleosome occupancies genome-wide in response to the individual deletion of 201 transcriptional regulators in Saccharomyces cerevisiae using MNase-seq, totalling nearly 1,000,000 possible mutant-gene interactions. more...