GEO DataSet Links for SRA (Select 31474709) - GEO DataSets

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Items: 2

Select item 3080227301.

CCC046, YF-17D vaccination, day 1, rep 1

Organism:: Macaca fascicularis

Source name:: Whole blood

Platform:: GPL22523
Series:: GSE253538

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Accession:: GSM8022730

ID:: 308022730

SRA Run Selector

Select item 2002535382.

Cynomolgus macaques as a translational model of human immune responses to yellow fever 17D vaccination

(Submitter supplied) The non-human primate (NHP) model (specifically rhesus and cynomolgus macaques) has facilitated our understanding of the pathogenic mechanisms of yellow fever (YF) disease and allowed evaluation of safety and efficacy of YF-17D vaccines. However, the accuracy of this model in mimicking vaccine-induced immunity in humans remains to be fully determined. We used a system biology approach to compare hematological, biochemical, transcriptomic, innate and antibody-mediated immune responses in cynomolgus macaques and human participants following YF-17D vaccination. more...