GEO DataSet Links for SRA (Select 31270893) - GEO DataSets

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Items: 2

Select item 3080095101.

PfDa01_ssDNA_rep2

Organism:: Escherichia coli

Source name:: E. coli C2566, phage lambda, plasmid pRSSM1.PleII, phage XP12, phage T4 AGT-, and Adenovirus

Platform:: GPL32081
Series:: GSE233932

Download data: TXT

Sample

Accession:: GSM8009510

ID:: 308009510

SRA Run Selector

Select item 2002339322.

Discovery of diverse DNA cytosine deaminases enables a single-enzyme method for base resolution methylation detection

(Submitter supplied) Cytosine deaminases have important uses in the detection of epigenetic modifications and in genome editing. However, the range of applications of deaminases is limited by their substrate preference. To expand the toolkit of deaminases, we developed an in-vitro approach that bypasses a major hurdle with their severe toxicity in expression hosts. We screened 175 putative cytosine deaminases, primarily from bacteria, and found enzymes with strong activity on double- and single-stranded DNA in various sequence contexts, including some without any sequence constraints. more...