GEO DataSet Links for SRA (Select 30912133) - GEO DataSets

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Links from SRA

Items: 2

Select item 3079667981.

S7_HIP_S2

Organism:: Macaca mulatta

Source name:: Hippocampus

Platform:: GPL27943
Series:: GSE249907

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Accession:: GSM7966798

ID:: 307966798

SRA Run Selector

Select item 2002499072.

(Submitter supplied) The hippocampus is especially susceptible to age-associated neuronal pathologies, and there is concern that the age-associated rise in cortisol secretion from the adrenal gland may contribute to their etiology. Furthermore, because 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) catalyzes the reduction of cortisone to the active hormone cortisol, it is plausible that an increase in the expression of this enzyme enhances the deleterious impact of cortisol in the hippocampus and contributes to the neuronal pathologies that underlie cognitive decline in the elderly. more...