GEO DataSet Links for SRA (Select 30894625) - GEO DataSets

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Items: 2

Select item 3079646101.

Animal_A14X078_W27_D0

Organism:: Macaca mulatta

Source name:: PBMC

Platform:: GPL32224
Series:: GSE249806

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Accession:: GSM7964610

ID:: 307964610

SRA Run Selector

Select item 2002498062.

Immunological assessment of multiple clinical-stage adjuvants to induce durable immune responses to the R21 malaria vaccine

(Submitter supplied) Authorization of the Matrix-M-adjuvanted R21 vaccine by three countries and its subsequent endorsement by the World Health Organization (WHO) for malaria prevention in children is a milestone in the fight against malaria. Yet, to meet the unprecedented demand for malarial vaccines, there is a pressing need for additional adjuvants that induce robust and durable vaccine-induced immunity. Here, we performed a comparative assessment of three clinically relevant adjuvants (an alum formulation of the TLR7/8 agonist 3M-052 (3M-052+Alum), the TLR4 agonist GLA-LSQ (GLA in liposome QS-21 formulation), and Matrix-M, the currently approved adjuvant for R21) for their capacity to induce durable immune responses to the R21 malaria vaccine in non-human primates. more...