GEO DataSet Links for SRA (Select 27885204) - GEO DataSets

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Links from SRA

Items: 2

Select item 3074013811.

DEC_rep4

Organism:: Mus musculus

Source name:: CMM

Platform:: GPL17021
Series:: GSE233096 GSE233099

Download data: TXT

Sample

Accession:: GSM7401381

ID:: 307401381

SRA Run Selector

Select item 2002330962.

STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia [RNASEQ_AML_DECSCR]

(Submitter supplied) Cultured acute myeloid leukemia (AML) blasts can differentiate into antigen-presenting cells but achieving leukemic cell immunogenicity proved challenging in clinical setting. Despite expressing multiple immunostimulatory receptors, such as Toll-like Receptor 9 (TLR9), AML cells resist immunostimulation. We previously demonstrated that eliminating Signal Transducer and Activator of Transcription 1 and 3 (STAT1/3) signaling in AML cells using decoy DNA strategy (CpG-STAT3dODN) synergized with TLR9 stimulation and resulted in T cell-mediated leukemia regression. more...