GEO DataSet Links for SRA (Select 2427926) - GEO DataSets

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Items: 2

Select item 3021140181.

SZ-1 miR-9 KD

Organism:: Homo sapiens

Source name:: SZ_hiPSC forebrain NPCs

Platform:: GPL16791
Series:: GSE80163 GSE80170

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Accession:: GSM2114018

ID:: 302114018

SRA Run Selector

Select item 2000801702.

Next Generation Sequencing Compares Effects of microRNA-9 perturbation in control and SZ hiPSC NPCs

(Submitter supplied) To follow-up findings that miR-9 was abundantly expressed in control NPCs, significantly down-regulated in a subset of SZ NPCs, and that miR-9 levels/activity, neural migration and diagnosis were strongly correlated, we tested the effect of manipulating miR-9 at cellular, proteomic and transcriptomic levels. Unexpectedly, proteomic- and RNAseq-based analysis revealed that these effects were mediated primarily by small changes in expression of indirect miR-9 targets, rather than large changes in direct miR-9 targets; these indirect targets are enriched for migration-associated genes. more...