GEO DataSet Links for SRA (Select 21972421) - GEO DataSets

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Items: 2

Select item 3046234781.

SMARCA4_786O_PBRM1KO_ChIPSeq_Rep1

Organism:: Homo sapiens

Source name:: Cancer cell line

Platform:: GPL16791
Series:: GSE152681 GSE152735

Download data: BED

Sample

Accession:: GSM4623478

ID:: 304623478

SRA Run Selector

Select item 2001526812.

Genome-wide chromatin profiles of PBRM1 [ChIP-Seq]

(Submitter supplied) PBRM1 encodes an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and the inactivation of PBRM1 is the second most frequent mutational event in kidney cancer. However, the impact of PBRM1 loss on chromatin remodeling, especially pertaining to kidney tumorigenesis, has not been well examined. Here we show that in VHL-deficient renal tumors, PBRM1 deficiency results in aberrant PBAF complexes that localize to de novo genomic loci and activate the pro-tumorigenic NF-?B pathway. more...