GEO DataSet Links for SRA (Select 19617311) - GEO DataSets

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Items: 2

Select item 3058487351.

WT luminal, BM1, RNA-seq

Organism:: Mus musculus

Source name:: PyMT tumor derived cell line, FACS purified luminal population

Platform:: GPL19057
Series:: GSE195715 GSE195716

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Accession:: GSM5848735

ID:: 305848735

SRA Run Selector

Select item 2001957152.

Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis [MARS-seq]

(Submitter supplied) The tumor suppressor LATS1, whose expression is often downregulated in human breast cancer, helps maintain luminal breast cancer cell identity by keeping basal-specific genes in a closed chromatin state, preventing their spurious activation. This is achieved via interaction of LATS1 with the NCOR1 nuclear corepressor and recruitment of HDAC1,driving histone H3K27 deacetylation near NCOR1-repressed “basal” genes. more...