GEO DataSet Links for SRA (Select 1580031) - GEO DataSets

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Items: 2

Select item 3017530091.

Alzheimer's Brain Sample53

Organism:: Homo sapiens

Source name:: DEM - LOW

Platform:: GPL16791
Series:: GSE70424

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Accession:: GSM1753009

ID:: 301753009

SRA Run Selector

Select item 2000704242.

UTRseq_human_brain

(Submitter supplied) Alternative polyadenylation (APA) contributes to post-transcriptional regulation, but its role in Alzheimer’s disease (AD) is largely unknown. Using high-resolution SQUARE multiple 3’ primer-based sequencing, we discovered massive APA differences in temporal gyrus tissues from demented AD patients compared to either healthy controls or non-demented donors with AD neuropathology (NDWP). Advanced statistics, microfluidics RT-PCR and protein measurements validated known and novel APA-modified 3’-intact transcripts. more...