GEO DataSet Links for SRA (Select 14699230) - GEO DataSets

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Items: 2

Select item 3053523391.

NFkB shRNA 1, 2'3'-cGAMP 2

Organism:: Nematostella vectensis

Source name:: whole embryos

Platform:: GPL29226
Series:: GSE175984

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Sample

Accession:: GSM5352339

ID:: 305352339

SRA Run Selector

Select item 2001759842.

Cyclic dinucleotide stimulation of Nematostella vectensis

(Submitter supplied) In mammals, the cGAS-cGAMP-STING pathway is crucial for sensing viral infection and initiating an anti-viral type I interferon response. cGAS and STING are highly conserved genes that originated in bacteria and are present in most animals. By contrast, interferons only emerged in vertebrates; thus, the function of STING in invertebrates is unclear. Here, we use the STING ligand 2'3'-cGAMP to activate immune responses in a model cnidarian invertebrate, the starlet sea anemone Nematostella vectensis. more...