(Submitter supplied) Recent evidence suggests that RNA interaction can regulate the activity and localization of DNA binding proteins, particularly chromatin-associated proteins. However, it is unknown if these observations are specialized instances for a few key RNAs and chromatin factors in specific contexts, or a general mechanism underlying the establishment of chromatin state and regulation of gene expression. Here, we introduce formaldehyde RNA ImmunoPrecipitation (fRIP-Seq), a sensitive method for cataloging RNA-protein interactions, to survey the RNA associated with a panel of 24 chromatin-associated and traditional RNA binding proteins.
more...- Organism:
- Homo sapiens
- Type:
- Expression profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing
- Platform:
- GPL16791
- 79 Samples
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