GEO DataSet Links for SRA (Select 1251599) - GEO DataSets

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Items: 2

Select item 3016073871.

H3K27ac Chip-Seq EpiSC

Organism:: Homo sapiens

Source name:: Epidermal Stem Cells

Platform:: GPL11154
Series:: GSE65838

Download data: BED

Sample

Accession:: GSM1607387

ID:: 301607387

SRA Run Selector

Select item 2000658382.

Dnmt3a and Dnmt3b associate with enhancers to regulate human epidermal stem cell homeostasis

(Submitter supplied) Here, we show that Dnmt3a and Dnmt3b show non-overlapping and unique patterns of genomic localization in human epidermal stem cells and their differentiated counterparts. Dnmt3a, but not Dnmt3b, binds to the TSSs of a cohort of genes required for the interaction of stem cells with their underlying stroma. Unexpectedly, TSSs bound by Dnmt3a are highly transcribed and are devoid of DNA-methylation. Conversely, Dnmt3b specifically decorates the genebody of genes that establish the stem cell and differentiated signatures. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing