GEO DataSet Links for SRA (Select 12080020) - GEO DataSets

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Items: 2

Select item 3048228661.

p20084-s008_RHz12_BAL_Day4_GEX

Organism:: Macaca mulatta

Source name:: bronchoalveolar lavages

Platform:: GPL27943
Series:: GSE159212 GSE159214

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Sample

Accession:: GSM4822866

ID:: 304822866

SRA Run Selector

Select item 2001592122.

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques [scRNA-Seq]

(Submitter supplied) SARS-CoV-2 induced hypercytokinemia and inflammation are critically associated with COVID-19 disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor, is currently being investigated in COVID-19 clinical trials. Here, we investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Viral shedding measured from nasal and throat swabs, bronchoalveolar lavages and tissues was not reduced with baricitinib. more...