GEO DataSet Links for SRA (Select 1199802) - GEO DataSets

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Items: 2

Select item 3015892071.

CCE.1_1

Organism:: Mus musculus

Source name:: CCE

Platform:: GPL13112
Series:: GSE65196

Download data: TXT

Sample

Accession:: GSM1589207

ID:: 301589207

SRA Run Selector

Select item 2000651962.

Single-cell DNA methylome sequencing and bioinformatic inference of epigenetic cell state dynamics

(Submitter supplied) Here we describe a method for whole genome bisulfite sequencing in very small cell populations (µWGBS) and in single cells (scWGBS). Our method is optimized for profiling DNA methylation in many samples at low coverage, and we developed a bioinformatic method that uses collections of single-cell methylomes to infer cell state dynamics. Using these technological advances, we studied epigenetic cell state dynamics in three in vitro models of cellular differentiation and pluripotency and identified patterns of epigenetic remodeling and cell-to-cell heterogeneity.