GEO DataSet Links for SRA (Select 1175023) - GEO DataSets

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Items: 2

Select item 3015719011.

H3K27ac marks of primed LIS2 ES stem cells

Organism:: Homo sapiens

Source name:: human ICM-derived ES cell line

Platform:: GPL11154
Series:: GSE52617 GSE52824

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Sample

Accession:: GSM1571901

ID:: 301571901

SRA Run Selector

Select item 2000526172.

Derivation of novel human ground state naïve pluripotent stem cells [ChIP-seq; RRBS-seq]

(Submitter supplied) Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3b signalling (termed 2i/LIF conditions). Hallmarks of naive pluripotency include driving Oct4 (also known as Pou5f1) transcription by its distal enhancer, retaining a pre-inactivation X chromosome state, global reduction in DNA methylation and in H3K27me3 repressive chromatin mark deposition on developmental regulatory gene promoters.Upon withdrawal of 2i/LIF, naïve mouse ES cells can drift towards a primed pluripotent state resembling that of the post-implantation epiblast. more...