GEO DataSet Links for SRA (Select 11133045) - GEO DataSets

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Links from SRA

Items: 2

Select item 3046235111.

Input_PCS400_ChIPSeq

Organism:: Homo sapiens

Source name:: primary renal proximal tubule epithelial cells

Platform:: GPL16791
Series:: GSE152681 GSE152735

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Sample

Accession:: GSM4623511

ID:: 304623511

SRA Run Selector

Select item 2001526812.

Genome-wide chromatin profiles of PBRM1 [ChIP-Seq]

(Submitter supplied) PBRM1 encodes an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and the inactivation of PBRM1 is the second most frequent mutational event in kidney cancer. However, the impact of PBRM1 loss on chromatin remodeling, especially pertaining to kidney tumorigenesis, has not been well examined. Here we show that in VHL-deficient renal tumors, PBRM1 deficiency results in aberrant PBAF complexes that localize to de novo genomic loci and activate the pro-tumorigenic NF-?B pathway. more...