GEO DataSet Links for SRA (Select 10039718) - GEO DataSets

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Items: 2

Select item 3042998291.

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Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL11154
Series:: GSE144874 GSE145092

Download data: BW

Sample

Accession:: GSM4299829

ID:: 304299829

SRA Run Selector

Select item 2001448742.

Intron looping is mediated by U1 snRNP and RNA polymerase II co-transcriptionally [ChIP-seq]

(Submitter supplied) In the earliest step of spliceosome assembly, the two splice sites flanking an intron are brought into proximity by U1 snRNP and U2AF. The mechanism that facilitates this intron looping is poorly understood. Using a CRISPR interference-based approach to halt RNA polymerase II transcription in the middle of introns, we discovered that the 5 splice site base pairs with a U1 snRNA that is tethered to RNA polymerase II during intron synthesis. more...