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Items: 2

1.

Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1

(Submitter supplied) Estrogen (E2) signaling through its nuclear receptor, estrogen receptor α (ERα) increases insulin-like growth factor 1 (IGF1) in the rodent uterus, which then initiates further signals via the IGF1 receptor (IGF1R). Directly administering IGF1 results in similar biological and transcriptional uterine responses. Our studies using global ERα-null mice demonstrated a loss of uterine biological responses of the uterus to E2 or IGF1 treatment, while maintaining transcriptional responses to IGF1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL20775
68 Samples
Download data: CEL, CHP
Series
Accession:
GSE100131
ID:
200100131

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

ERa DNA Binding Profiles of IGF1 and ICI182,780 treated mouse uterus from manuscript: Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1

(Submitter supplied) Estrogen (E2) signaling through its nuclear receptor, estrogen receptor α (ERα) increases insulin-like growth factor 1 (IGF1) in the rodent uterus, which then initiates further signals via the IGF1 receptor (IGF1R). Directly administering IGF1 results in similar biological and transcriptional uterine responses. Our studies using global ERα-null mice demonstrated a loss of uterine biological responses of the uterus to E2 or IGF1 treatment, while maintaining transcriptional responses to IGF1. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: BEDGRAPH
Series
Accession:
GSE100023
ID:
200100023

PubMed Full text in PMC Similar studies SRA Run Selector

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