GEO DataSet Links for PMC (Select 4279401) - GEO DataSets

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Items: 3

Select item 2000566301.

Expression profiling of MDA-MB-231 breast cancer cells treated with DOT1L inhibitors and siDOT1L

(Submitter supplied) MDA-MB-231 cell line with relatively high DOT1L levels was treated with two potent, selective inhibitors of the DOT1L histone methyl transferase. These compounds can inhibit cells migration and invasion and induce differentiation. Here we provide expression profiling data of cells treated with two DOT1L inhibitors [1] [2], DOT1L siRNA (siDOT1L) or control.

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS5619 GDS5620
Platform:: GPL10558
12 Samples

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Series

Accession:: GSE56630

ID:: 200056630

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56202.

H3K79 histone methyl transferase DOT1L inhibitor Compound 55 effect on breast cancer cells: dose response

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor Compound 55 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL10558
Series:: GSE56630
8 Samples

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DataSet

Accession:: GDS5620

ID:: 5620

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56193.

H3K79 histone methyl transferase DOT1L inhibitor EPZ004777 effect on breast cancer cells: dose response

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor EPZ004777 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.