GEO DataSet Links for PMC (Select 3899689) - GEO DataSets

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Items: 2

Select item 2000469241.

27-Hydroxycholesterol links cholesterol and breast cancer pathophysiology.

(Submitter supplied) The cholesterol metabolite and SERM, 27HC, is the signaling molecule that links cholesterol to breast cancer pathophysiology Hypercholesterolemia is a risk factor for breast cancer, and patients taking statins demonstrate lower breast cancer incidence and decreased breast cancer recurrence, data that highlights the potential importance of the recent finding that 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol, acts as a selective estrogen receptor modulator (SERM). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4765
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE46924

ID:: 200046924

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 47652.

Breast adenocarcinoma MCF-7 cell line response to 27-Hydroxycholesterol and estradiol

Analysis of MCF-7 cells treated with 27HC in the presence of E2. 27HC, a primary metabolite of cholesterol and an estrogen receptor (ER) ligand, increases ER-dependent growth in mouse models of breast cancer. Results provide insight into a relationship between hypercholesterolemia and breast cancer.