GEO DataSet Links for PMC (Select 3163806) - GEO DataSets

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Items: 2

Select item 2000281461.

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease

(Submitter supplied) Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray study correlated gene expression in human hippocampus with AD markers. Results suggested a new model of early-stage AD in which pathology spreads along myelinated axons, orchestrated by upregulated transcription and epigenetic factors related to growth and tumor suppression (Blalock et al., 2004). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4136
Platform:: GPL570
30 Samples

Download data: CEL

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Accession:: GSE28146

ID:: 200028146

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 41362.

Various stages of Alzheimer's disease: laser-captured hippocampal CA1 gray matter

Analysis of laser-captured hippocampal CA1 gray matter from FFPE hippocampal sections of subjects at varying stages (incipient, moderate, severe) of Alzheimer’s disease (AD). Results provide insight into gray matter-specific molecular mechanisms underlying AD.