GEO DataSet Links for PMC (Select 3033342) - GEO DataSets

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Items: 2

Select item 2000283591.

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

(Submitter supplied) Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSCs identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3911
Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE28359

ID:: 200028359

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 39112.

StemRegenin 1 effect on hematopoietic stem cells: dose response

Analysis of hematopoietic stem cells (HSC) treated with StemRegenin 1 (SR1) and LGC006 (a less potent SR1 analog) at 30nM to 1000nM. The use of HSC transplants depends on the ability to expand these cells ex vivo. Results provide insight into molecular basis of SR1-induced ex vivo HSC expansion.