GEO DataSet Links for PMC (Select 1193619) - GEO DataSets

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Items: 2

Select item 2000022961.

Effects of inducible HIV-1 Vpr protein on cellular gene expression

(Submitter supplied) Three 293 cell-derivative cell line were constructed using commercially available Invitrogen Flp-In TREx 293 cells. The cell lines express wild type HIV-1 Vpr and two mutant Vprs, F72A/R73A and R80A. The mutant Vprs are defective in the Vpr cell cycle arrest phenotype. The cell lines were characterized for their ability to express Vpr at the RNA and protein levels and functionally for the ability of the inducibly expressed Vprs to arrest cell cycle progression at G2/M. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1875
Platform:: GPL1528
87 Samples

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Accession:: GSE2296

ID:: 200002296

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 18752.

Host cell response to HIV-1 Vpr-induced cell cycle arrest: time course

Analysis of cell lines expressing wild-type or mutant HIV-1 Vpr protein at various timepoints following doxycycline induction. Vpr advances HIV pathogenesis by inhibiting the cell cycle at G2/M. Results identify changes in cellular gene expression associated with Vpr-mediated cell cycle arrest.