GEO DataSets

(Submitter supplied) During early mammalian development, DNA methylation undergoes two waves of reprogramming, enabling transitions between somatic cells, oocyte and embryo. The first wave of de novo DNA methylation establishment occurs in the oocytes. Its molecular mechanisms has been studied in mouse, a classical mammalian model. Current dogma describes DNA methyltransferase 3A (DNMT3A) and its cofactor DNMT3L as two essential factors for oocyte DNA methylation – the ablation of either leads to nearly complete abrogation of DNA methylation. more...

Organism:

Cavia porcellus; Spalacopus cyanus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL30845 GPL33695 GPL28437

7 Samples

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